I've had muscle twitches for quite a few years now. I don't remember them as a teenager, but it's been at least since I was diagnosed with FM/CFS back in 2004. I get muscle twitches all over my body at random, at least a few hundred times a day. It's very subtle and other people can't actually see it unless you're actually looking at the muscle when it happens. Anyway, is this related to the FM? I had seen a neurologist a number of years ago who did an EMG, nerve conduction study, and an MRI...all of which were completely normal. The problem is that these muscle twitches (aka fasciculations) leave my muscles feeling sore after a while...almost like I've run a marathon. The neuro I had seen back then had prescribed Topamax, which I took for a couple months. I didn't notice a difference with it, so I ended up stopping it because I couldn't handle the side effects. Anyone else get these muscle twitches?