chrissy12 - Mycoplasma What if your antibodies to mycoplasma pneumoniae are above 1000, usually 1200 and as high as 1600 for a long period of time? I have been on doxycycline for 2-1/2 years. Do you have any other suggestions to bring the numbers down? Do you think there is any connection between the retrovirus XMRV and mycoplasma? Reply: Generally when antibody titers to M. pneumoniae are that high, you likely still have an active infection. Such infections can take quite a bit of time to successfully suppress, and in truth you never really eradicate all of the mycoplasma. These infections can hide deep inside of cells in inactive (persistent) forms that are not very susceptible to most effective antibiotics. However, most patients will eventually recover on long-term antibiotic therapy plus immune enhancement, lipid replacement and other supplements. Most chronic illness patients have Mycoplasma infections. For example, the majority of CFS and FMS and other fatiguing illnesses have these infections. There is no apparent connection between the XMRV virus and intracellular bacteria like Mycoplasma, Borrelia, Chlamydia and other commonly found bacteria in CFS, except for the notion that XMRV may affect the immune system and its ability to prevent or attenuate bacterial infections.