MYELOPEROXIDASE (MPO)anyone familiar with this..

Discussion in 'Fibromyalgia Main Forum' started by ulala, Mar 20, 2007.

  1. ulala

    ulala New Member

    I have had positive labs for P-Anca and C-Anca. Also postivie NEURTOPHIL CYTO AB. The lab sheet says "nearly 90% of P-Anca positive sera from patients with glomerulonepritis have myeloperoxidase (MPO) antibodies. a confirmation test which can be ordered separately.

    MYELOPEROXIDASE is a break down fo the immune system. It seems that it could be related to CFS/FM.

    Background: Myeloperoxidase (MPO) is a human enzyme in the azurophilic granules of neutrophils and in the lysosomes of monocytes. Its major role is to aid in microbial killing. Although MPO received little clinical attention until 1966, the enzyme was first isolated in 1941, and deficiency of MPO was first described in 1954. Some patients with MPO deficiency have impaired microbial killing, but most are asymptomatic, and the condition usually are undiagnosed. Because most cases are undiagnosed, the condition was initially believed to be very rare; only 15 cases were reported before the 1970s. However, modern laboratory techniques have allowed researchers to discover that MPO deficiency is actually not so rare.

    MPO also chlorinates phagocytosed bacteria directly; thus, the MPO–hydrogen peroxide–Cl system seems to have an important role in microbial killing. Although the exact mechanism by which microbial killing occurs is controversial, researchers are fairly certain that the MPO system is important for the process to occur optimally.

    In addition to killing bacteria, the products of the MPO–hydrogen peroxide–Cl system are believed to play a role in killing fungi, parasites, protozoa, viruses, tumor cells, natural killer (NK) cells, red cells, and platelets. The MPO–hydrogen peroxide–Cl system is also believed to be involved in terminating the respiratory burst, because individuals with MPO deficiency have prolonged respiratory bursts. It may play a role in down-regulating the inflammatory response. This system can also down-regulate NK cells, decrease peptide binding to chemotactic receptors, and auto-oxidize and inactivate products of PMNs, such as a1-proteinase inhibitor and chemotaxins

  2. ulala

    ulala New Member

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