A number of years ago I began taking NADH. I took 5mg for a while, then I increased it to 12.5 mg which ProHealth carries. Recently I talked with my ME,CFS specialist and he told me if I could afford it to up my dose of NADH to a minimum of 20mg. I began taking 12.5 mg twice a day. Wow! can literally feel the energy going through me at this higher dose. It's been two weeks and each time I take the second dose I experience the sensation of energy traveling though me. Has anyone else been on a dose this high of NADH? If so, how long have you been taking it and what has been your experience with the higher dosing? I am so hoping this is not a temporary reaction to a new dose. With ME so often we start something, have good results with it for a time, and then it stops doing anything discernable. It is great that ProHealth supplies this product at a number of dosages and at good price points.