Naltrexone May Ease Fibromyalgia Symptoms

Discussion in 'Fibromyalgia Main Forum' started by JLH, Oct 27, 2009.

  1. JLH

    JLH New Member

    Naltrexone May Ease Fibromyalgia Symptoms ......

    Preliminary Study Shows That Low-Dose Naltrexone May Be an Effective, Low-Cost Treatment for Fibromyalgia

    An inexpensive drug called Naltrexone may make a good treatment for fibromyalgia, report researchers at Stanford University.

    Naltrexone isn't a new drug; it's been around for more than 30 years and is used to treat opioid addiction.

    Stanford's Jarred Younger, PhD, and Sean Mackey, MD, PhD, tested a low dose of naltrexone as a fibromyalgia treatment in 10 women who had had fibromyalgia for about 10 years, on average.

    First, the women spent two weeks recording the severity of their fibromyalgia symptoms every day using a handheld computer. And they took lab tests to gauge their fibromyalgia pain and sensitivity to heat and cold.

    After that, the women took a placebo pill every day for two weeks, but they didn't know it was a placebo pill. At the end of the placebo period, the women took a naltrexone pill once a day for eight weeks. Finally, they spent the last two weeks of the study not taking naltrexone or the placebo.

    All along, the women continued to rate their fibromyalgia symptoms every day, and they repeated their lab tests every two weeks.

    While taking the placebo, the women reported a 2.3% drop in the severity of their fibromyalgia symptoms, compared to their symptom ratings at the start of the study.

    When they switched from the placebo to naltrexone, they reported an additional 30% drop in their fibromyalgia symptom severity.

    The women also showed greater tolerance for pain and for hot (but not cold) temperatures while taking naltrexone.

    Most of the women -- six out of 10 -- responded to naltrexone.

    Side effects were mild and brief.

    Two women reported having more vivid dreams during the study, and one woman reported transient nausea and insomnia during the first few nights of taking the pills, note Younger and Mackey.

    The study, which appears online in Pain Medicine, was a small, preliminary project to see if low-dose naltrexone showed promise. It did, so Younger and Mackey are already working on a new study that will test low-dose naltrexone in 30 fibromyalgia patients for 16 weeks.

    By Miranda Hitti
    WebMD Health News
    Reviewed by Louise Chang, MD

    April 17, 2009
  2. kat0465

    kat0465 New Member

    I have been on LDN 4.5 mg for about 2 months now, and after the first week, i realized when i woke up in the mornings i could actually walk with hardly any pain in my feet and legs, before i couldnt hardly get out of the bed.

    as far as anyting else, i havent noticed an improvement, but still hoping things will get better the longer i take it.
    No side effects, except some vivid dreaming, but even thats a plus. cause for over 3 years i really havent dreamed at all, i guess cause i never get in the deep rem cycle of sleep. so it's helped that some.
    so far its good, it'snon addictive, dosent make you constipated, and no major side effects. so if your Dr. will prescribe, i say go for it. the only down side i can see is Ins dosent pay for it( but not too expensive) and you have to have it compounded down to a small dose.
    Good Luck All
  3. street129

    street129 New Member

    i have to go pick up my LDN TOMORROW, $38.bucks, i have to gave them. i hope it works for me. i've been having a not so good 2009 health wise.

    my other years, i was able to do things at 75-80%
    [This Message was Edited on 10/27/2009]
  4. victoria

    victoria New Member

    even if the studies are 'preliminary' etc... ;)

    LDN has always fascinated me. I don't have pain tho, happily ... wonder if it would help clear the head from the fog from lyme, CF/FM/ME, etc.

  5. victoria

    victoria New Member

    I too never showed up on blood tests as low, but my body temps have always been below normal, my 'normal' is about 97. Once I tried what amounts to Cytomel in early 1990s, felt the best I ever had, but my MD made me wean off it to see if I could do without, as recommended. Unfortunately at the same time I went thru the worst stress in my life, and that didn't work; I also never felt the same again even tho I went back to my original dosage. So I went back to armour as it was cheaper; couldn't tell any diff at that point anyway.

    Over the prior years to the above, I'd slowly upped my armour thyroid med to 3 grains with my MDs okay, but never really felt any difference.

    However, while doing phase 1 of the marshall protocol, I suddenly got a (minor) thyroid storm... so under my doc's advice and they tell you this can happen on the forum there, I dropped it by 1/2 and was fine. A few months later it happened again, this time I weaned off to 0. All tests remain the same, as does my body temp however.

    I have tried a small dose again, but immediately got the hyperthyroid symptoms again (after only 2 days), so dropped it. I think cortisol would still help me, but can't get it in MX, only prednisolone which doesn't work for me. I did have someone bring me an adrenal support formula with dessicated adrenal gland instead... which works. Low dose cortisol, imho, is not used enough.

    I've 'searched' a few times to see what those with Lyme report, but haven't seen much re it helping/or not helping the 'brain fog'...

    good luck with it!