I'm not exactly new to this board, but I haven't posted but maybe once. Tuesday I saw a new DO for help managing my pain, and she prescribed Effexor. I had taken this many years ago for depression before I was correctly diagnosed with bipolar disorder and put on Topamax - what a life saver! Anyway, I was diagnosed with FM/CFS in May 07 and am currently taking Lyrica, Topamax (which also helps with my migranes), Ambien, and now Effexor. I feel so out of it, it is inbelievable. The pain has lessened to some degree, but this feeling scares me. Is this typical? Will is go away as my body adjusts to this medicine? Is it an effect in conjuntion with the Lyrica? I'm currently on a medical leave, but have to go back to work on July 7th (hopefully), and I sure as heck can't go feeling like this. Sorry so long, any advice would really be appreciated.