Neurotoxin Discovered in Chronic Fatigue Syndrome

Discussion in 'Fibromyalgia Main Forum' started by AmyKaiser, May 3, 2003.

  1. AmyKaiser

    AmyKaiser New Member

    Press Release

    National CFIDS Foundation Inc.
    Needham, Massachusetts

    Contact Information:
    Gail Kansky 781-449-3535
    Jill McLaughlin 978-475-0232

    Neurotoxin Discovered in Chronic Fatigue Syndrome

    Needham, MA November 17, 2002 -- Research sponsored by the National CFIDS
    Foundation was formally announced at the International Symposium on Toxins
    and Natural Products in Okinawa, Japan on November 17-19, 2002 by Dr.
    Yoshitsugi Hokama. The research, for the first time, discovered ciguatoxin,
    a potent neurotoxin, in the blood of Chronic Fatigue Syndrome patients.

    "Chronic ciguatera poisoning has already been suggested as a scientific
    model for Chronic Fatigue Syndrome (CFS)," stated Dr. Hokama. Ciguatoxins
    are potent, heat stabile, non-protein, lipophilic sodium channel activator
    toxins and are recognized as some of the most potent biological toxins
    known. They produce dramatic neurological manifestations, such as peripheral
    sensory or motor symptoms (including paresthesias, pain, burning, tingling,
    numbness), central symptoms such as headache, autonomic dysfunction and also
    affect multiple body systems (gastrointestinal, immune, hepatic, cardiovascular)
    and the muscles.

    Many CFS patients in the study had higher levels of the toxin than the
    patients with cancer, hepatitis or acute ciguatera poisoning.

    Quantitative assay results range from 1:5, the lowest toxin level, to
    1:160, the highest toxin level. All CFS samples gave titres of at least
    1:20, with the majority of titres from 1:40 to 1:160.

    Dr. Hokama presented his preliminary findings in a lecture titled "Acute
    phase lipids in sera of various diseases: Chronic Fatigue Syndrome,
    ciguatera, hepatitis, and various cancer with antigentic epitope resembling
    ciguatoxin as determined with Mab-CTX."

    Dr. Hokama is a Professor in the Department of Pathology at the John A.
    Burns School of Medicine at the University of Hawaii at Manoa. He is a
    world expert in the area of fish toxins with hundreds of peer reviewed
    publications to his credit. Hokama developed the Membrane Immunobead Assay
    test for patient sera, using a specific monoclonal antibody for ciguatera
    toxin (Mab-CTX). His current research into Chronic Fatigue Syndrome and a
    ciguatera toxin connection was funded by the National CFIDS Foundation's
    research grant program.

    Gail Kansky, President of the National CFIDS Foundation, said, "We believe
    this to be a significant breakthrough. CFS, which has come to include
    myalgic encephalomyelitis, is a very severe illness that has not received
    adequate funding or appropriate medical attention. Although there are still
    many unanswered questions and much work to be done, research efforts will
    ultimately turn the tide in the understanding of this disease and allow
    patients to receive appropriate medical therapies. We are indebted to Dr.
    Hokama and his colleagues for providing this monumental first step."


    For more information on this study or Chronic Fatigue Syndrome, please
    contact:

    The National CFIDS Foundation
    103 Aletha Road
    Needham, MA 02492
    phone: 781-449-3535
    fax: 781-449-8606

    Related Links:

    Click here for the abstract of the presentation given by Dr. Yoshitsugi Hokama at the International Symposium on Toxins and Natural Products in Okinawa, Japan on November 17-19, 2002. C

    Click here for the full text of the Journal of Toxicology: Toxins Review (2003) paper titled "Chronic phase lipids" in sera of several chronic diseases reacting with MAb-CTX (antibody to ciguatoxin) by Y. Hokama et. al. (in the printable PDF file format).

    Click here for the full text of the Journal of Clinical Lab Analysis (2003) article titled "Chronic phase lipids" in sera of Chronic Fatigue Syndrome (CFS), Chronic Ciguatera Fish Poisining (CCFP), Hepatitis B, and Cancer with Antigenic Epitope Resembling Ciguatoxin as Assessed with MAb-CTX" by Y. Hokama et. al. (in the printable PDF file format).

    Click here for the full text of the Neurology of ciguatera article by Dr. John Pearn (in the printable .PDF file format).
    Click here for the text-only version.

    Ciguatera Testing is Now Available! For information, click here.

    Click here for Ciguatera Toxin FAQ.


    The National CFIDS Foundation * 103 Aletha Rd, Needham Ma 02492 * (781) 449-3535 Fax (781) 449-8606
  2. gcalex

    gcalex New Member

    From what I can tell this is VERY preliminary and nothing definitive has come of this yet.
  3. scubadiver

    scubadiver New Member

    There's more recent info. Yes, preliminary but very significant. This is not acute cigua poisoning!
    For some reason the blood of chronically ill people
    have been coming up positive to date more than
    a couple hundred people. Many who have been
    diagnosed with CFIDS/Fibro are positive.
    My own personal stats
    of people I know who have tested positive also
    have tested pos for lyme or mycoplasma.
    Something to keeo any eye and to certainly test for.