How many people with CFS or FMS have had gallbladder disease and/or gallbladder removal out there? Jellybelly's information regarding “ HYPERCOAGULATION Linked to Chronic Fatigue, Fibromyalgia and Infertility" started me thinking and then doing some reading/research as well. In the Allergy Research Group newsletter, "Focus", dated August 2002, I found the following excerpt: “Additionally, binding therapy with the cholesterol-lowering drug Cholestyramine is an option in treating some of these patients. This drug has a complimentary positive charge to the generally negative charge of the neurotoxin and as the neurotoxin-bile complex passes the Sphincter of Oddi where bile is released from the gallbladder, it binds neurotoxins linked to bile, which can then not be reabsorbed. Prolonged use of Cholestyramine has proven to be disappointing in patient out-comes whereby the infection is of a chronic nature. Cycling of Cholestyramine has been utilized (5 days on, 10 days off) or an early AM single dose for several months. In our clinical experience we have found that venous Phospholipid Exchange is one of the most efficient ways of clearing the liver and biliary tree which are paramount in addressing neurotoxic syndromes. Oral use of phospholipids in a Liver Flush is also an effective intervention. Blood thinning agents such as Heparin and Warfarin increase blood flow around the damaged endothelium, however, reconstituting membrane fluidity can directly address coagulation in a natural restorative way. Vibrant healthy membranes will not permit agglomeration.” It would stand to reason that the absence of or malfunction of the gallbladder where the neurotoxin links to bile from the gallbladder might cause hypercoagulation. The Cholesteryramine mentioned is used to treat IBS as well. In addition, could the problem be related (not caused by but related) to elevated levels of cholesterol? I have read possible causes of elevated cholesterol being due to lack of bile. There may be a link here as well to levels of cholesterol. I have had removal of the gallbladder some 33 years ago and have had IBS since the removal. Lately, I have had elevated cholesterol levels. Even with modified diet the cholesterol doesn't seem to come down. Could there be an intrinsic link?