I have been going to a number of different dr's over the past 8-10 months and no one can seem to figure out what is going on or what to do. A little background - I have been treated for depression for the past 10 years (the diagnosis of depression was because of constant fatigue, not significant mood problems) and for hypothyroid for the past 3-4 years (again the result of complaints of constant fatigue, but that time at least my blood work showed something). I have always had less energy than your average person, but over the past 8-10 months it has gone to the extreme. I am pretty much always exhausted to the point where I feel ill (aches&pains, migraines, nausea) and a lot of times to the point where I can barely function. I can make myself stay awake so I'm pretty sure it doesn't have anything to do with narcolepsy (even though my drs have resorted to putting me on Provigal, which is a narcolepsy drug, just so that I can get through the day). There have been several times that I have been afraid to drive because I can't focus and my reaction time is shot - I've lost track of the number of near miss car accidents. I've had pretty much every blood test known to man and all ok - all of my thyroid levels are perfect, no diabetes, no lupus, nothing. The only blood test that was a little abnormal was ANA, but when all the the specific lupus tests came back negative my dr said the positive ANA was most likely because my hypothyroid was being caused by Hashimoto's (an autoimmune disorder that attacks and eventually detroys your thyroid), but unfortuneately there is no specifc treatment for Hashimoto's - you just treat the hypothyroid, which in my case is being treated fine and not my problem. So now my dr is starting to lean towards Chronic Fatigue Syndrome. He is actually the second dr to mention this possibility to me. He hasn't gone into possible treatment options with me yet, because he wants to try one last thyroid thing - he put me on Cytomel to take along with my Synthroid. He said that wasn't really an accepted practice in the medical community, but he has had a few patients with normal thyroid levels and very persistant hypothyroid symptoms that responded well to it. What I am trying to find out is what does it mean if this is actually Chronic Fatigue Syndrome? From what I have read there aren't a whole lot of treatment options - antidepressants seem to be the standard treatment. But I have already tried about 80% of the antidepressants out there and it hasn't helped. All I know is I can't keep living like this, please tell me there is something else that can be done.