New Med Tested for LOW BACK PAIN It Seems To Work

Discussion in 'Fibromyalgia Main Forum' started by JLH, Jun 4, 2006.

  1. JLH

    JLH New Member

    In difficult-to-treat low-back patients, an investigational opioid appears to control pain without requiring dose escalation once there is relief, researchers reported here.

    "That was a surprising finding to me and a pleasing one as well," said Richard Rauck, M.D., of Wake Forest, in Winston-Salem, N.C., who discussed the drug in a poster presentation at the American Pain Society meeting here.

    Dr. Rauck said that these difficult-to-treat patients, once on a dose of Oxymorphone extended-release that reduced pain sufficiently, stayed on that dose through the 12 weeks of the trial. "In addition, in open-label extension trials, patients have been on stable doses for at least as long as seven months," he said.

    The patients were also put on a rigorous anti-constipation protocol, he said, which appeared to lessen side effects. During the titration phase of the study, 18.7% of the patients discontinued the trial due to adverse side effects.

    Dr. Rauck and colleagues recruited 250 patients into the study. In the first phase, the patients were titrated with oxymorphone until their pain was under control. Then the patients were randomized to receive a continuation of the oral drug or a placebo.

    Eventually 70 patients were on oxymorphone and 72 were on placebo. Rescue pain medication was made available for patients who had discomfort. After randomization, the average increase in the visual analog scale score - based on 100 points - rose by 30 points for placebo patients compared with a rise of about six points for patients on oxymorphone. That difference reached statistical significance at the P<.0001 level, Dr. Rauck said.

    Before the trial only 15% of patients said they felt their pain medication was either very good or excellent. "In general, people with chronic low back pain are pretty unhappy," Dr. Rauck said, and he gave that as one reason for a high dropout rate during the titration period. At the end of the study 22% of the placebo patients felt their medication was very good or excellent compared with 58% of those on oxymorphone (P<.0001).

    "We can always use another opioid," said Michael Weinberger, M.D., at anesthesiologist at Columbia in New York. "The data to date suggest that there is more than one receptor for pain and genetic differences mean different people react differently to drugs. It would be nice to offer out patients another alternative."

    Oxymorphone is being reviewed by the FDA, with a decision expected by the end of June. (Yeah!)

    Although nausea, constipation, headache, somnolence and vomiting were major causes of adverse events during the initial titration phase of the trial, but there were few complaints after randomization.

    "Oxymorphone extended release - taken twice a day - appears to be an appropriate round-the-clock treatment option in patients who may need a change in opioid to effectively manage chronic moderate to severe low back pain,: Dr. Rauck said.

    SAN ANTONIO, May 8, 2006
  2. alaska3355

    alaska3355 New Member

    This is good info- I plan to tell my mom about it. She has a bad back due to herniated discs. Thanks!
  3. JLH

    JLH New Member

    I have a lot of back problems and severe low back pain, due mainly to a pinched nerve in that area and I have found NOTHING that will help my low back pain.

    Well, my heating pad does help, I guess.

  4. tandy

    tandy New Member

    Now the problem,......
    getting a doc. to write out a script for a opiod pain reliever.
    I've given up.
    I regularly see 3 different drs. for my pain conditions
    and not 1 of them think we need the stronger end pain meds. I get ultram.
    They help, but not much. I surely would'nt give praise to ultram. The relief is too minimal~

    keep on keepin on
    :) Tandy