NEW Positive Confirmation Study: XMRV in Respiratory Tract Study!

Discussion in 'Fibromyalgia Main Forum' started by KnightofZero, May 18, 2010.

  1. KnightofZero

    KnightofZero New Member

    New Article Must See:

    Xenotropic Murine Leukemia Virus–related Gammaretrovirus in Respiratory Tract

    Thanks to those who originally found this paper which confirms the presence of XMRV in healthy population at a level of 3-4%, and about 10% in immunodeficient--a new finding.

    This is the "German Study" mentioned in another topic, to avoid confusion. There was only one study but it was a big one =). [This Message was Edited on 05/18/2010]
  2. KnightofZero

    KnightofZero New Member


    XMRV, originally identified in RNase L–deficient patients with familial prostate cancer, has gained interest since recent work showed its protein expression in as many as 23% of prostate cancer cases (10) and XMRV-specific sequences were detected in PBMCs of 67% patients with chronic fatigue syndrome (5). These results, however, could not be confirmed by others (6–8). Both studies also detected XMRV protein or sequences in their control cohorts with frequencies of 6% and 4%, respectively.

    Among the most pressing information gaps with regard to XMRV is its preferred route of transmission. Detection of XMRV in PBMCs and plasma of patients with chronic fatigue syndrome raises the possibility of blood-borne transmission; sexual transmission has also been hypothesized on the basis of indirect evidence (5,9). We detected XMRV in respiratory secretions of immunocompetent patients with and without RTI at a frequency of ?3.2%, which is in good concordance with the recently reported prevalence in the general population of up to 4% (5). Frequency of XMRV detection in group 1 patients (2.25%) was comparable to that of human metapneumovirus and rhinovirus within this group and considerably less frequent than that of parainfluenzavirus (15.5%) or influenza A virus (7.6%) detection (11).

    Our findings indicate that XMRV or virus-infected cells might be carried in and transmitted by the respiratory tract. Attempts to isolate infectious virus from XMRV sequence–positive respiratory samples failed, possibly because of inadequate storage of samples before virus culturing attempts or relatively low copy numbers of the virus within the samples. Thus, whether the respiratory tract serves as a putative transmission route for XMRV cannot be determined at this time. The observed increase in prevalence among immunosuppressed patients with RTI suggests that XMRV might be reactivated in absence of an efficient antiviral defense. Together with earlier observations on increased XMRV replication in RNase L–deficient cells (1,12), this finding implies that the immune system plays a role in controlling XMRV replication. It remains unknown whether immunosuppression predisposes a patient to secrete infectious XMRV from the respiratory tract or whether presence of virus might be meaningless for epidemiology in a way similar to HIV-1 (15).

    Future studies should address whether the respiratory tract might serve as a source of XMRV infection or whether immunosuppression might cause an increased risk for primary infection.""

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