New study DISMISSES virus link to chronic fatique--link

Discussion in 'Fibromyalgia Main Forum' started by quanked, Dec 20, 2010.

  1. quanked

    quanked Member

    IS THIS NEW INFO ? Anyone have any thoughts on what this means?

    XMRV, once connected to debilitating condition, is a lab contaminant, researchers say

    By Kate Kelland
    updated 12/20/2010 11:45:19 AM ET 2010-12-20T16:45:19
    Share Print Font: + - LONDON — A virus previously thought to be linked to a baffling condition known as chronic fatigue syndrome is not the cause of the disease, scientists said on Monday after their study found previous research was contaminated in the lab.

    Researchers from University College London, the Wellcome Trust Sanger Institute and Oxford University said cell samples from patients in earlier studies were contaminated with the virus, known as XMRV, which is found in the DNA of mice.

    This suggests the patients were not infected with XMRV and it could not have triggered their illness, the scientists said.

    The finding, published in the journal Retrovirology, is the latest to contradict a U.S. study from 2009 which suggested a link between XMRV and chronic fatigue syndrome (CFS) when the virus was found in the blood of 68 out of 101 CFS patients. The XMRV virus has also been identified in samples from certain prostate cancer patients.

    "Our conclusion is quite simple: XMRV is not the cause of chronic fatigue syndrome," said Greg Towers, of UCL, who worked on the latest study. "All our evidence shows that the sequences from the virus genome in cell culture have contaminated human chronic fatigue syndrome and prostate cancer samples."

    CFS is a debilitating condition of disabling physical and mental fatigue that does not improve with rest. It also known as myalgic encephalomyelitis (ME) and affects around 17 million people worldwide. There is no cure for CSF and scientists don't know what causes it, but many sufferers say they think their illness started after a viral infection.

    Cell line
    Towers said it was vital to understand that this latest research did not suggest chronic fatigue syndrome is not caused by a virus of some sort. "We cannot answer that yet," he said. "But we know it is not this virus causing it."

    The 2009 U.S. study that found a link had prompted hopes that CFS patients might benefit from a range of drugs designed to fight AIDS, cancer and inflammation.

    But in January 2010, British researchers found no evidence of XMRV in 186 patients with chronic fatigue syndrome, and two separate studies published in February also failed to identify the virus in groups of ME patients.

    Towers' team said their study found that the XMRV found in the studies that linked it to CFS was from contamination by a laboratory cell line or mouse DNA. The sequences from the contaminated cell line and chronic fatigue patient samples were very similar, they said, and this is contrary to what scientists would expect from a virus if it were spreading in humans.

    Tim Peto, a consultant in infectious diseases at Oxford University who was not involved in the research, said Monday's findings meant "it now seems really very, very unlikely that XMRV is linked to chronic fatigue syndrome".

    "It came as a great surprise when XMRV was first suggested as being linked to chronic fatigue syndrome," he said in an emailed statement. "There have now been a number of attempts which have failed to find the retrovirus in other samples, and this research suggests that in fact XMRV is probably a contamination from mouse DNA." (Editing by Alison Williams)

    Copyright 2010 Thomson Reuters. Click for restrictions.

  2. victoria

    victoria New Member

    I'm not surprised to see a study coming out of Britain tho saying it doesn't exist as it seems they are invested in the psychological approach. Now if they lift the ban on donating blood, that might get more interesting.

    (I don't really have an opinion one way or another; just waiting to see what happens like most of us.)

  3. AuntTammie

    AuntTammie New Member

    This possible issue was addressed very thoroughly by the WPI when the question came up before......I am way too exhausted to try to explain all the reasons that they pretty clearly proved that it was extremely unlikely to have happened, but if you go to their website, I think they may still have that info there

    and since then the FDA study also came out showing retroviral issues - I doubt that they had contamination issues AND the WPI did

    the british "studies" showing no XMRV had about a million flaws - they were clearly trying to stick with their psych b/s
  4. jole

    jole Member

    I find it strange also that if it shows NO connection to CFS, why are the CFS patients coming back to this day with positive xmrv results? I believe these retrovirals can definitely be...if not the cause of...connected to more than one diagnosis. How can they say otherwise, and why?
  5. cfs since 1998

    cfs since 1998 New Member

    WPI has posted a statement on their website to counter the contamination papers.

    "The Lombardi et al. and Lo et al. studies were done using four different methods of detection. They were not simply PCR experiments, as were the studies by McClure et al. and others who have recently reported their difficulties with contamination..."

    Dr. Kenny DeMeirler is also reported on a blog to have made a statement.
  6. luigi21

    luigi21 Member

    Yes, englands results were negative for XMRV, Rheumatologists opinions vary here, some think its neuropsychological, some think its a dysfunction of the Central Nervous System, i have 2 Rheumatologists with opposing views which makes it interesting. That said they are looking into the fact that a hepatitis type virus may still be involved in these conditions, that said humans probably have alot of unknown virus's which there finding all the time, it doesn't mean they are linked to these conditions though. When testing for virus' they are testing for antibodies these tell you what virus's the body has had but doesn't necessarily prove a link to causation of a condition, hope this helps.


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