New Therapies in Fibromyalgia.

Discussion in 'Fibromyalgia Main Forum' started by JLH, Jul 8, 2006.

  1. JLH

    JLH New Member

    Biology and Therapy of Fibromyalgia.
    New Therapies in Fibromyalgia.


    ABSTRACT:

    Fibromyalgia is a chronic, musculoskeletal pain condition that predominately affects women. Although fibromyalgia is common and associated with substantial morbidity and disability, THERE ARE NO US FOOD AND DRUG ADMINISTRATION-APPROVED TREATMENTS. However, progress has been made in
    identifying pharmacological and non-pharmacological treatments for fibromyalgia.

    Recent pharmacological treatment studies have focused on selective serotonin and norepinephrine reuptake inhibitors, which enhance serotonin and norepinephrine neurotransmission in the descending pain pathways and lack many of the adverse side effects associated with tricyclic
    medications.

    Promising results have also been reported for medications that bind to the alpha2delta subunit of voltage-gated calcium channels, resulting in decreased calcium influx at nerve terminals and subsequent reduction in the release of several neurotransmitters thought to play a role in pain processing.

    There is also evidence to support exercise, cognitive behavioral therapy, education, and social support in the management of fibromyalgia.

    It is likely that many patients would benefit from combinations of pharmacological and non-pharmacological treatments, but more study is needed.

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    SOURCE:
    Arthritis Res Ther. 2006 Jun 1;8(4):212 [Epub ahead of print]

    Arnold LM.

    Women's Health Research Program, University of Cincinnati College of Medicine, Piedmont Avenue, Cincinnati, Ohio 45219, USA. Lesley.Arnold@uc.edu.

    PMID: 16762044

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    OK now!!!!!!! Who can interpret what the paragraphs regarding the pharmacological treatment studies says????!!!!!!!!!!! LOL



  2. IntuneJune

    IntuneJune New Member

    I was thinking "what the heck" and then read "OK now, who can interpret" and then laughed

    We do have way more neurotransmitters floating around in our cerebrospinal fluid.....so a drug that would reduce the release of neurotransmitters into our CSF would have an affect on the amount of pain we feel.

    Over 25 years down this road, I have never been impressed with tricyclics.

    Finding proper exercise was very important in my improvement.

    Fondly, June