I am so happy to tell you this. I wanted to let you guys know what has stopped my awful leg cramps. I have posted and read here before trying to find some help. Since I got CFS/FM I have been suffering very bad leg and foot cramps every night, sometimes so bad that I thought I couldn't bear it. Spasms that sent my foot pointed straight down and rock-hard, my big toe sticks straight up, and different leg muscles lock into cramps that I could not break for several minutes. Sometimes they would last as long as 30 minutes before I got them to calm down enough to go back to sleep (putting an ice pack on my lumbar area helped calm the leg nerves). After the cramps my legs were like jelly, popping muscles and jiggling nerve feelings. I have been blaming these cramps on my lumbar nerve compression. I have told every doctor about these cramps and there was never any advice but yet another drug to try. Early this year my cardiologist listened to me describe the cramps. He looked thoughtful and told me to take 800 IU Vitamin E right at bedtime. I thought he was nuts. If Vit E stopped leg cramps, why hadn't I heard about it on the web? I have researched everywhere. So I looked up Vit E and got a little unnerved by the fact that you can take too much (>1,000 IU isn't recommended) and I have been nervous about taking 800 IU so I have been taking 400 every night. The Vit E worked right away, within a couple days even at the lower dose. I wasn't having nightly cramps any more, only an occasional one. I have been taking this dose-400- for a few months now and have only had minor leg issues occasionally but none of those killer cramps. I told the doctor last week about my transformation and said I wanted to know why in the world this works? He said they don't know, but that Vit E was found accidentally to relieve leg cramps. Ok well, that's good enough for me. I will never stop taking this supplement, ever again. By the way, I had always taken a multiple vitamin but that never helped. And I have to take the Vit E right when I get in bed. I also had trouble with Vit E in soybean oil. It made me sick. I take Vit E in safflower oil. It's easier on my stomach. Good luck to those of you who try it. These cramps were ruining my life.