I thought I'd post about my experiences with Xithromax since alot of people were wondering at the study that was done with it. I've had CFIDS since 91, completely disabled by it. I'm mostly housebound now. My doctor and I had both read about the study that was done with 500mg's of Xithromax three days a week. The study claimed that about sixty percent of the patients who took it got about eighty percent better after six weeks. Well, it's been nine weeks now. Has it helped? Somewhat, but not the eighty percent I was hoping for. More like five to ten percent. I have alittle more stamina. It is the difference between my being able to make dinner or washing a dish. I've had the stamina to do a few things I couldn't do before. I was able to clean out my fridge. But I paid for it the next day in typical CFIDS fashion filled with severe pain and flare symptoms. I have more stamina to be on the pc longer and do the hobby work I do on here. I do notice that. I can even talk to one of my friends on chat, where before, I really couldn't do that. I didn't feel I had the stamina or energy. But all of these things are really only about five to ten percent better than I was before. I still haven't felt I could drive or do much of anything else. Some of my pain is better on the Xithromax. But only some of it. My fibro pain, that got better. It does nothing for my arthritis. For the first time in half a lifetime, I have color back in my face. I no longer look like I ate arsenic wafers or had my blood drained. I'm usually pale as a corpse. I have actual skin color. It's so odd to me now. I've been so pale that even the lightest shade of base makeup was too dark for me. I think my head is clearer for the first time in a long time. I don't feel foggy. However, it does nothing for the short term memory loss. That's just as bad as ever. Xithromax has horrible stomach side effects. You can get uncontrollable diarrhea on it at any time. The first three weeks on the antibiotic were so bad with it that I didn't want to stick out taking it. But by the fourth week, my stomach was a bit better with that. I still get upset stomachs on the days I take it, but it's better during the rest of the week. Fatigue and stamina are two different animals. I am still fatigued. But I have more stamina. So I can make dinner, but I'm very tired doing it. But that stamina/life energy is now there to do so. I don't know if I would recommend trying Xithromax as a treatment for CFIDS. I'd probably say no. I don't think the little bit of better is worth the stomach problems. Like what good is it if you are better, but you now can't leave the house because of the stomach problems? Plus, it's no miracle cure. It's not even a great treatment. And if I had known I would only have five to ten percent better, I don't know if I would have done it. I have no idea why it has helped alittle bit and not more. Maybe I've had it too long, I'm too old? I don't know. The ones it helped in the study were younger. I'm thirty-seven now. And I've had this for a very long time. There are other reasons it might have helped alittle bit. Maybe I had a latent Lyme infection or something else. Who knows. That might have been compounding the disease. But it's obviously not the cause of it. Whatever this illness is, I still got the November clogged ear, even while on this stuff. That's something you can set your watch by with me. I get sick every November since I got the illness. So, all I can say is, it's probably viral or micoplasmal and not bacterial. Clear-headed is not always such a good thing. I now get to really see what the illness has done to my life and there is nothing I can do about it. It's not for lack of trying. I am starting to feel like a cat chasing its tail. I can't beat the disease. I've tried everything. Nothing works. So there you have it. Xithromax is no miracle cure. And if you want to try it, it may or may not help you. I did have hope when I started it. The hope is now fading and I'm not sure I'll stay on it because it's not doing more. It's just sort of staying like this and the stomach problems aren't worth it.