I just had more blood work done and apparently I have so little estrogen and testosterone that the levels didn't even register in my blood....and my pregnenolone and DHEA are both low (they are precursors to the other two)....not sure if this has anything to do with ME/CFS (as a cause or effect), or if it doesn't, but some of the symptoms of both are sure familiar: fatigue, muscle weakness, overheating, hair loss, dry skin, weight gain, bloating, loss of muscle and inability to build new muscle, moodiness, pain, trouble breathing, etc, etc. The Dr said that since I am on the birth control pill (for endometriosis), he isn't sure about how to treat this problem. Normally he would use a topical hormone cream, but he usually uses that for patients not on the pill. I have tried many, many times to go off the pill, but have felt absolutely horrible (physically and emotionally) and have had periods that don't want to end, so I am not sure what to do. He told me that I would be a guinea pig if I stayed on the pill and added the topical stuff, and that does not make me too comfortable, plus the topical stuff is expensive and not covered by medicare. I suggested trying pregnenolone, since it is a precursor hormone and seems to be well tolerated by many people. He thought that seemed like something worth trying. So, that's what I am going to do, but for some reason this whole thing has me kind of freaked out.....maybe bc I am feeling like an androgynous freak, maybe bc it's just one more thing wrong with me and it seems that everything new I try makes me feel worse.....maybe bc it's just one more reason why it is so difficult for me to maintain a normal weight (& the harder it gets the more I want to revert to just not eating - & I know that would obviously be bad)....oh and maybe it's freaking me out, bc I have never had a Dr seem blown away by my test results before (he pretty much said that my body and its responses to several things - not just this - does not make any sense........the good thing, though, is that he does believe me and he does listen, and is willing to keep trying some new things) So, I was wondering if anyone else has had any similar test results and/or has tried taking pregnenolone, and what their experience was like?