Noxylane4 for NK cell activity?

Discussion in 'Fibromyalgia Main Forum' started by deliarose, Oct 19, 2006.

  1. deliarose

    deliarose New Member

    Hi
    my new doc is recommending Noxylane4 by Lane Labs to help boost my Natural Killer cell activity.

    It's barely there.'

    Wondering if anyone has tried and seen results?

    tnx
    delia
  2. Slayadragon

    Slayadragon New Member

    What is your NK Cell activity, just out of curiosity's sake? Mine is 1/4 the normal value.

    Have you had other immune system components tested? Like Rnase? Or oxidative measures of cell death? Or viral load? Or anything else?

    Is Noxylane 4 a prescription or over-the-counter?

    What kind of doctor are you seeing?

    Thank you for the information......I'd like to look into this.
  3. deliarose

    deliarose New Member

    my NK count was 5 on a scale where 8-170 would be normal.

    No, I haven't had more extensive virus load testing done...No doc has ever offered it to me.

    I feel better on the TFs.. and I had acute CFS onset after a nasty virus.. so that suggests I'm on the right track.

    Noxylane4 was suggested by a new doc I am seeing..Andrea Rentea in Chicago.

    It's a supplement by Lane Labs. She sells it in her practice for $60 a bottle.

    I posted about this on the CFSExperimental yahoo group.. and someone there sent me a study.. check it out if you're interested.

    delia
  4. deliarose

    deliarose New Member

    if u see this...can u remind me of the name of the probiotic your doc recommended?

    I think i remember u mentioning one brand by name.


    here's a link to the post about Noxylane4 on the other list i mentioned.


    http://health.groups.yahoo.com/group/CFSFMExperimental/message/108156

    tnx
    delia
  5. deliarose

    deliarose New Member

    Description
    Double Strength
    HAI Potentiated

    Clinically Shown to Increase NK Cell Activity
    Dietary Supplement Noxylane4T is the next generation in immune
    defense from LaneLabs. It contains Arabinoxylane-a patented rice bran
    hemicellulose modified by Shiitake mushroom enzymes-and HAIT. Heated
    Algal Ingredient (HAI) is a patented amino acid complex from Japanese
    seaweed clinically shown to enhance absorption.

    Supplement Facts
    Serving Size: 2.00 cpt
    Servings per container: 25.00

    Amount Per Serving % Daily Value
    Calories 4.00
    Total Fat 0.00 g 1%
    Total Carbohydrate 0.00 g 1%
    Proprietary Blend (Arabinoxylane Compound) 1,000.00 mg
    Rice Bran *
    Hyphomycetes Mycelia Enzyme (from Shiitake Mushroom) *
    HAI Amino Acid Extract (from Sea Algae) 0.00 mg *
    *Daily value not established.
    Other ingredients: Microcrystalline Cellulose, Croscarmellose Sodium,
    Stearic Acid, Silica, Magnesium Stearate, Hydroxypropyl
    Methylcellulose and magnesium Silicate.
    _____________________________________________________________
    Title: Anti-HIV activity in vitro of MGN-3, an activated
    arabinoxylane from rice bran.
    Author: Ghoneum M
    Source: Biochem Biophys Res Commun, 243(1): 25-9 1998
    Service Fee: $12.00 ; Copyright Royalties: $32.00

    Abstract: MGN-3 an arabinoxylane from rice bran that has been
    enzymatically modified with extract from Hyphomycetes mycelia, was
    tested for anti-HIV activity in vitro. MGN-3 activity against HIV-1
    (SF strain) was examined in primary cultures of peripheral blood
    mononuclear cells. MGN-3 inhibited HIV-1 replication by: (1)
    inhibition of HIV-1 p24 antigen production in a dose dependent manner-
    -MGN-3 concentrations of 12.5, 25, 50, and 100 micrograms/ml showed
    18.3, 42.8, 59, and 75% reduction in p24 antigen, respectively; and
    (2) inhibition of syncytia formation maximized (75%) at
    concentrations of 100 micrograms/ml. Further studies showed that
    ingestion of MGN-3 at concentration of 15 mg/kg/day resulted in a
    significant increase in T and B cell mitogen response at 2 months
    after treatment: 146% for PHA, 140% for Con A, and 136.6% for PWM
    mitogen. We conclude that MGN-3 possesses potent anti-HIV activity
    and in the absence of any notable side effects, MGN-3 shows promise
    as an agent for treating patients with AIDS.
    _____________________________________________
    NoxylaneT4 clinical research

    To test the activity of Noxylane4, LaneLabs commissioned two separate
    pilot studies by doctors and scientists at Research Testing Labs of
    Great Neck, NY. Both studies measured the support of Noxylane4 at 1.5
    grams (6 capsules/day) in humans. 1.5 grams a day is a much lower
    intake versus other immune products.

    Blood was drawn from each participant at the start of each study and
    4 weeks after taking Noxylane4. In the first trial an additional
    blood sample was taken after 1 week. Results were averaged and
    analyzed for statistical significance.

    In the first trial blood samples were evaluated for Natural Killer
    (NK) cell support.. The second trial measured NK support and other
    general immune system markers (Lymphocytes ­ which include B cells and
    T cells ­ and CD56/CD16 values). <---NK cell markers

    Trial 1 suggested improved NK support in 4 weeks taking 1.5 grams of
    NoxyLane4 per day. (Some patients saw no improvement)

    http://www.lanelabs.com/products.asp?
    productID=Noxylane4&pageID=clinicalResearch
    Graph (What are the values on the x y axis?)

    Trial 2 involved healthy patients, given either Noxylane4 (at
    1.5g/day) or arabinoxylane alone (without HAIT) at 3g/day. In just 4
    weeks the Noxylane4 group demonstrated favorable in NK cell support,
    Lymphocytes and CD56/CD16 values, similar to the group taking twice
    as much arabinoxylane daily.

    That is one reason we consider Noxylane4 LaneLabs' biggest health
    discovery ever.
    Your results may differ.
    _________________________________________________________
    This looks like an upgrade from their MGN-3.
    As others may have had experience with MGN-3 that may be useful to
    you or for others to comment/extrapolate from. dunno, but this may
    help others to comment and help you out. I do know the MGN-3 has
    been around awhile, first saw this vendor at a show in 99? some were
    questioning their graphing skills. Trial 1 was for n=20 (relatively
    small sample size and they don't state the "humans"/"participants"
    have CFIDS, a.k.a. "low NK cell disease" in Japan) and implies a
    tripling of NK cell activity...if that is true, i would take it.
    can't recall seeing MGN-3 on recommended lists of NK boosters for
    CFS. i don't know what they mean by NK "support". Trial 2 implies
    that by adding the HAI to improve absorption they were able to give
    half the dose to get the same result which was?, favorable
    NK "support". As i recall the original ingredient was
    arabinogalactan.



  6. deliarose

    deliarose New Member

    that any of these studies were done independently...
    at least 2 seem to have been underwritten by the manufacturer.

    just for what it's worth...

    cheers
    delia
  7. Slayadragon

    Slayadragon New Member

    OK, I now know exactly what this is, and had a discussion with someone on this site about what seems to be the same substance only a week or two ago. Look under my posts....it should be titled something having to do with Natural Killer Cells, MGN-3 (I originally spelled it wrong as MGM-3), AHCC or Mushrooms.

    First, my NK activity is about 1/4 of low-normal. My Rnase is also about 1/4 of low-normal. My viral load (total number of viruses of all kinds that my body carries around) is 40x high-normal. (This comes from a state-of-the-art test I just had done. I wish more people on this board would ask their doctor to let them get it, so that I could compare my results.)

    Anyway, as you can see, my immune system is way messed up. It would take a lot to fix it.

    About 5 years ago, I spent a couple of months on a product called MGN-3. It was made out a special kind of mushrooms, and is supposed to be the most popular CFS supplement in Japan (where CFS is called Natural Killer Cell Dysfunction Disorder).

    I got a herx the entire time. I thought it might end eventually, but when it kept going on, I finally decided to give up. The super-high cost (that experiment probably cost several hundred dollars) was another factor.

    Now it seems that MGN-3 has been removed from the U.S. marketplace by the FDA for making cancer-cure claims. (I don't understand why anyone would think Natural Killer Cell activation would help cancer, but never mind.) Now it seems to have been replaced in products with what seems to me exactly the same thing, AHCC. (Claims for AHCC is that it is "even more effective than MGN-3.")

    Anyway, I am sure this stuff does something. The problem is, my immune system is in such bad shape that even if this stuff makes the Natural Killer Cells a little more activated, I don't think it ever would kill off all those viruses. Maybe if my immune system were in only somewhat bad shape, it would have been helpful.

    I am going to try an anti-viral drug soon. I have been thinking recently (since that post) that if the anti-viral kills off a good chunk of my viral load, this (and/or long-term high-dosage ProBoost) might be a good adjunct (e.g. to get rid of whatever leftover viruses that particular drug doesn't destroy). I will ask my doctor if I get to that point.

    It would be interesting to try that mushroom stuff (by whatever name) and see just how much my NK Cell activity did increase (according to the lab test). And it sounds like if a pharmaceutical company were to pick up on it and make it a whole lot stronger, it might have some potential then too. More potential than any other immune-boosters I've heard about, anyway.
  8. Slayadragon

    Slayadragon New Member

    Oh, yes. This stuff is sold on the ImmSupport store (look at the tabs at the top of this page) under the name ImmPower (something like that). You can at least use it as a comparison to what your doctor's suggesting.
  9. deliarose

    deliarose New Member

    pro-boost, mushrooms, MN3, NOxylene4

    How the hell are u supposed to know if any of this stuff is effective, or worth the money?

    I guess all u can do is shell out the money and monitor your NK cell activity .. although whether there's a direct correlation, god only knows.

    I assume a heavy viral load wld suppress your NK numbers..and therefore they might not go up until you get that down..

    Ouf.

    Anyway Lisa.. a quick question.

    Has Guyer had any success with his treatments?

    Does he have patients who have more or less recovered and gone back to work?

    Is there any evidence out there that CFS patients are recovering?

    delia