well, here goes, I am going to try to type in a summary of the Oprah article. I think it has some good info and want everyone to have a chance at it. Excerpts: "You Think You're Tired?" by Mary A. Fischer from O magazine, Sept. 2006 . . . news. Scientists at the CDC had (have) found credible evidence of a biological cause for CFS (chronic fatigue syndrome) . . . **(they found) people with chronic fatigue syndrome have a genetic quirk that causes them to overrespond to physical and emotional stress. (CFS or FMS) can be as debilitating as multiple sclerosis and AIDS. . .Many don't recover, . . . (some say) "I never feel anything close to well." onset can be sudden or gradual . . many keep pushing themselves. . . CFS was first recognized in the mid-1980's. . .For the groundbreaking CDC study, published in the April 2006 issue of "Pharmacogenomics, 227 volunteers patients and healthy controls--checked into a Wichita hospital. . .teams delved into genetics and found that the DNA code in people with CFS is different in genes that are important to both the immune and sympathetic nervous systems--pointing in particular, to 3 genes related to the hypothalamic-pituitary-adrenal axis, which affects the stress response. . .CFS VOLUNTEERS HAD WHAT'S CALLED A HIGH ALLOSTATIC LOAD the cumulative wear and tear on the body resulting from inadequate biological responses to changes in the everyday environment as well as to emotional and physical stressors. . .in healthy people, those immune cells would adapt to the trauma and start healing the body. . . .With the results of the study researchers predict that a diagnostic test and treatment for CFS are only 3 to 5 years away. . . (Some say) that CFS is where multiple sclerosis used to be 25 years ago before MRI scans identified the disease's biological marker--lesions in the brain. . .