OT: Brain Changes In Patients With Migraine...

Discussion in 'Fibromyalgia Main Forum' started by kjfms, Oct 21, 2006.

  1. kjfms

    kjfms Member

    20 Oct 2006

    Researchers from Harvard Medical School have found increased thickness of two areas of the brain cortex in people with migraine when compared to healthy controls.

    Both areas of the brain are known to be involved in how the brain processes signals to do with movement.

    Using two forms of magnetic resonance imaging the researchers studied 24 patients with migraine (12 who had migraine with aura and 12 without aura) and 15 age-matched healthy controls.

    There were no differences in cortical thickness in motion-related areas between the participants with migraine who had aura (neurological disturbances such as illusions of flashing lights, zig-zag lines, or blind spots) and those who did not, but the area of cortical thickening in one area corresponded to the source of cortical spreading depression previously identified in a person who had migraine with aura.

    As well as showing that there are some structural differences in the brains of people with migraine, the position of the changes could help to explain why some people with migraine have problems with visual processing even in between attacks.

    In a Perspective article commenting on the work Peter Goadsby from the Institute of Neurology, London said "the new data show that after four millennia, migraine still has many more secrets to be uncovered."


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    Citation: Granziera C, DaSilva AFM, Snyder J, Tuch DS, Hadjikhani N (2006) Anatomical alterations of the visual motion processing network in migraine with and without aura. PLoS Med 3(10): e402.

    PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://dx.doi.org/10.1371/journal.pmed.0030402

    Nouchine Hadjikhani
    Harvard Medical School
    HMS/MGH/HST Martinos Center for Biomedical Imaging
    Building 36, First avenue. #417
    Charlestown, MA 02129 United States of America

    Related PLoS Medicine Perspectives article:

    Citation: Goadsby PJ (2006) The migrainous brain: What you see is not all you get? PLoS Med 3(10): e404.

    PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://dx.doi.org/10.1371/journal.pmed.0030404

    Peter Goadsby
    University College London
    Institute of Neurology
    Queen Square
    London, United Kingdom

    About PLoS Medicine

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    Article URL: http://www.medicalnewstoday.com/medicalnews.php?newsid=54354

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    Thanks for reading,

    Karen :)
  2. abcanada

    abcanada New Member

    I found this VERY interesting, as I've been experiencing daily migraines for almost two years. Seemed to be brought on by pregnancy, but they have not gone away. About the same time I've been experiencing an extremely bad flare. No tests have shown anything, and I'm having an MRI next week. Should be interesting to see if they see any of this stuff in my bean. one doc thinks it may be MS or something Neurological, another doesn't think so, just that I have FM and to take two Advil and it'll be ok(NOT), and another thinks I have a migraine disorder. They all wasted sooo much time saying that my body had been through hell and back(pregnancy), and to give it time and I'd feel better. My thing is that something must be causing it. Well I'll let you know in a couple of weeks what shows up, if anything. Get this, here in Canada I've been waiting 6 months for my MRI, was originally not booked until the end of Feb 2007! Laura
  3. kjfms

    kjfms Member

    Hi Laura -- I really hope you find some help. My goodness that is such a long time to wait for MRI. Please do keep us posted on the outcome.

    Hi Hayley -- I so agree with being on preventative medication. I take Topamax and do pretty well with it -- doesn't get rid of them but does lessen the severity somewhat.


    Karen :)
  4. mezombie

    mezombie Member

    I have a lot of problems with visual processing, so I was particularly interested that the article mentioned that. I get "classic" migraines as well, but they are for the most part under control with medication.

    When I get "motion sickness" due to visual stimulation, I've been told I have a "vestibular migraine". Unfortunately, I haven't been able to find anything to help with these symptoms.

    It's great to know there's some objective physical evidence related to this --it may lead to some treatment some day!
  5. Jeanette62

    Jeanette62 New Member

    Thanks for posting this article...very interesting.

    I wonder if my MRI indicated these changes since I have problems with visual processing. I'll have to bring this article to my next appt with my neuro and ask him what his opinion. He has specialized in treating headaches and migraines for 20+ years and runs the local headache support group. He keeps current on a lot of the research.

  6. darude

    darude New Member

    I have an article I will post about Migraines. Thanks for article.