OT: Inflammatory Bowel Disease Gene ID'd

Discussion in 'Fibromyalgia Main Forum' started by kjfms, Oct 26, 2006.

  1. kjfms

    kjfms Member

    Original page:

    Gene Is Likely One of Several Linked to IBD, Researchers Say

    By Miranda Hitti

    WebMD Medical News
    Reviewed By Louise Chang, MD on Thursday, October 26, 2006

    Oct. 26, 2006 -- Scientists have spotted what they suspect is the first of several genes tied to inflammatory bowel disease (IBD).

    The gene is called IL23R. It's noted by Yale University's Judy Cho, MD, and colleagues in Science's early online edition.

    Inflammatory bowel disease includes Crohn's diseaseCrohn's disease and ulcerative colitisulcerative colitis. Its exact cause is unknown.

    About a million people in the U.S. have IBD, according to the National Institute of Diabetes and Digestive and Kidney Diseases.

    The gene discovery is "not a gene test" for IBD, and it's "not going to be an immediate panacea" for people with IBD, Cho tells WebMD. "But we have a lot better information, and the power of information, I think, is going to hopefully make a difference."

    For instance, the gene findings may eventually lead to new drugs to treat IBD.

    "It basically says, 'OK, let's put this at the top of the list of things that we should really work on,'" Cho says.

    Inflammation Link

    "Inflammatory bowel disease is an uncontrolled chronic inflammation of the intestines," Cho tells WebMD. "As you might imagine, the inflammatory process is very complex.

    "Imagine a fire where there's all kinds of things that are contributing to the fire," Cho says. "The power of genetics is that it identifies ... the trigger that started the whole process."

    A certain chemical pathway in the body, called the interleukin-23 pathway, was highlighted in other IBD studies, Cho notes.

    "Now the genetics says the same thing," Cho says.

    Gene Study

    Cho's team checked the DNA of nearly 1,000 people with Crohn's disease and almost 1,000 people without either form of IBD. All participants were whites of European descent.

    The scientists looked for DNA differences in the patients and the people without IBD.

    Several variations of the IL23R gene -- which rules the interleukin-23 pathway -- stood out.

    In particular, people with an uncommon gene variation were two to four times less likely to have Crohn's disease, Cho says.

    "So instead of thinking about the genetics of disease, maybe you should be thinking about the genetics of health," Cho says.

    Next Steps

    Cho and colleagues are continuing their gene studies.

    "Undoubtedly, there are other genes" involved in IBD, Cho says. "We think that there's going to likely be at least several others."

    It will be important to do IBD gene studies in people of other ethnic backgrounds, she notes.

    As for new treatments, drug companies may be able to make antibodies that block the interleukin-23 pathway.

    That strategy would be "very effective at tamping down inflammation, but it might be almost too potent," Cho says. "We have the inflammatory response to fight off infection."

    A better approach might be to mimic the protective gene variant, Cho suggests.

    "You would tamp down inflammation in a way that you're not more prone to develop infections," she says, calling the development of such drugs "a long-term goal."

    Tailoring Treatment

    One day, genetics might help predict IBD's severity in patients and tailor treatment, Cho notes.

    "It's a raging debate in IBD:

    Are we better off when someone gets newly diagnosed with going with the big guns that potentially have more side effects, or are we better off starting with the safest drug that's maybe not as effective as some of the other ones and stepping up as patients need," she says.

    "If you take a combination of IBD genes and predict these courses, that might be a logical way of individualizing therapies, or at least giving patients more information so that they can make informed decisions about their medical therapies," Cho says.


    SOURCES: Duerr, R. Science, Oct. 26, 2006; online "Science Express" edition. National Institute of Diabetes and Digestive and Kidney Diseases: "Assessing Digestive Diseases Research and Treatment Opportunities." Judy Cho, MD, associate professor of medicine and genetics, director, Inflammatory Bowel Disease Center, Yale University.


    Karen :)
  2. KateMac329

    KateMac329 New Member

    Thanks again Karen for your diligence!!!!

    Bumping for others to see!

  3. i suffer from fibromyalgia and ME chronic fatigue syndrome.i also have irratable bowel syndrome,but i do not have the type that makes my food waste runny,its more the type that makes my food waste hard,but i do eat a banana every day,and i eat museli for breakfast every day too,so im able to go to the toilet with ease.

    i take a colofac tablet 20 mins before each meal,and that eases that gripeing pain that i used to get after eating a meal.

    but what i have noticed very often over the years is this..

    when im going through a very bad flare of the fibro/ME i dont get a feeling of wanting to go to the toilet for a pee,or the other.the flare can last a week,but when the flare has gone.i cant hold my pee,and need to go to the toilet alot,and often dont make it in time.

    its much the same for needing to empty my bowels too.im wondering if muscles inside our body,also swell up.during a fibro flare,and that stops us going to the toilet.then when the muscles arent in a flare,our bladder and bowel are no longer prevented from working properly,and so we have a back log of waste that is suddenly pushed out from our body.

    i do the pelvic floor excersizes daily as instructed to do by the nurse.but i still get the problems mentioned above.im sure in my own mind that internal muscle swelling causes most of our problems with our bowel and bladder.

    kind regards

  4. MamaDove

    MamaDove New Member

    Thanks so much for this info Karen...

    A few of us here have Crohn's and/or UC...

    We are thankful you posted this info...

    I will look into it further...

    libra55 (Michelle) will likely read this too...HI MICHELLE!

    I am very interested in the European descent aspect...

    Okay, just woke up from a night of bad dreams and not focussing yet, so I will print later...Thanks again Hon!
  5. kjfms

    kjfms Member

    Well I have to be honest the first person I thought of when I saw this is my sister she has suffered with Crohn's for years and is one though cookie -- never misses work, never complains she makes me feel like such a wimp.

    I know she suffers horribly because of this I have seen what Prednisone has done to her...just awful. It breaks my heart thank goodness there are alternatives now.

    Hi Kate -- Thanks for the bump :)

    Hi Fran -- Bless your heart I hope it gets a little better for you and you find something to help.

    Hi Mamadove -- I wanted to post this because I was pretty sure there were several here who had this problem too. I wish everyone with it the best.

    Take care all,

    Karen :)
    [This Message was Edited on 10/27/2006]
  6. libra55

    libra55 New Member

    I have always felt there is a genetic component to Crohn's. Being adopted I could never ask anyone about family history! This was a very informative article.

    Hi to you to Alicia.....I hope you're keeping well these days.

    I hope all the other Crohnies on this board will see this.

  7. kjfms

    kjfms Member

    Yes I have always thought genetics play a very important role in illnesses too. In our family we have Crohn's on both sides.

    I have found -- while doing family research -- that an aunt died of spinal meningitis at 6 months and an uncle died of "not being able to eat" at the age of 2-3 months (really can find no further information on this one) this was in the 1920s.

    Michelle so sorry you can't find information on your birth family maybe some day you will.

    Hayley your family sounds like my dad's side cancer and more cancer. Dad had 14 siblings all but 2 have died of some sort of cancer this also includes his mother.

    I agree with your physician/friend.

    Take care,

    Karen :)
  8. razorqueen

    razorqueen Member

    Thanks for posting this. As alot of you know my daughter Jerica has Crohns. The funny thing is, we do not know of anyone in either of our families that have IBD.

    I have IBS, but have been scoped and do not have either. Its a hard thing to deal with. It seems like I am the one who is doing most of the work! I know I'm not physically dealing with CD,[lots of otherthings] but I am on the net researching. No one else takes an interest.

    I guess if Jerica had more time she would too, and the time will probably come when she will. Right now she is busy trying to live a teenagers life of school, boyfriend and part time job, as well as going to her church youthgroup and sing occasionally on the praise and worship team.

    I am being her rock, my rock, and my husbands. Good thing my son is healthy!