I've had unequivocal results from NEw Life Colostrum Immune Formula w/olive leaf extract in combination with L-Glutathione and ARA-Luria w/olive leaf extract. My daily regimen includes a sustained release multi-vitamin, a trace mineral supplement, an easily digested amino acid blend, ARA-Luria, L-Glutathione, and the Colostrum. Adding Cytomel to my synthroid replacment regimine helped a bit with the cognitive problems (my low thryoid diagnosis came years before the CFS, and was well-managed with Synthroid only until I got CFS). HOWEVER - the results from these supplements are minimal, and I do not hold out hope that I will see significcant improvement as a result of taking them. Cheers, all!