I'm experiencing my worst relapse so far(4 years with CFS) and it seems to be due to CMV and Mycoplasma infections. Both Igm titers are sky high. I tried taking Doxycycline orally, but vomited for 3 days and ended up in the hospital for another 3 days. My PCP is unwilling to order IV antibiotics. I've also looked into the anti-virals for CMV, but the side effects may be more harmful than helpful. If any of you out there have experience with these infections, please drop me a line!