Oxidative stress in FM

Discussion in 'Fibromyalgia Main Forum' started by tansy, Nov 15, 2005.

  1. tansy

    tansy New Member

    Antioxidant status, lipid peroxidation and nitric oxide in fibromyalgia:
    etiologic and therapeutic concerns.

    Rheumatol Int. 2005 Nov 10;:1-6 [Epub ahead of print]

    Ozgocmen S, Ozyurt H, Sogut S, Akyol O, Ardicoglu O, Yildizhan H.

    Division of Rheumatology, Department of Physical Medicine and
    Rehabilitation, Faculty of Medicine, Firat University, 23119, Elazig,
    Turkey, [log in to unmask]

    PMID: 16283318


    We proposed to assess the oxidant/antioxidant status, lipid peroxidation
    and nitric oxide (NO) in untreated fibromyalgia (FM) patients and controls.
    The effect of amitriptyline (A, 20 mg daily) and sertraline (S, 100 mg
    daily) treatment on patients' superoxide dismutase (SOD), xanthine oxidase
    (XO), adenosine deaminase (ADA) enzyme activities, thiobarbituric acid
    reactive substances (TBARS) and NO levels was investigated.

    Thirty female patients with primary FM and age-matched 16 healthy female
    controls were included. Patients received an 8-week course of treatment
    with either A or S.

    FM patients had higher serum levels of TBARS (particularly malondialdehyde)
    and lower levels of nitrite compared to controls whereas enzyme activities
    were similar. A and S significantly improved Fibromyalgia Impact
    Questionnaire (FIQ) pain scores, Hamilton anxiety and depression rating
    scales. But neither A nor S had significant effects on measured oxidative
    stress parameters, except SOD activity that was significantly reduced after
    S treatment. Total myalgic scores negatively correlated with XO activity,
    and depression scales negatively correlated with levels of TBARS.

    Our results indicate that patients with FM are under oxidative stress.
    These findings represent a rationale for further research assessing the
    effect of free radical scavengers or antioxidant agents like vitamins and
    omega-3 fatty acids on peripheral and central mechanisms in FM.
  2. Mikie

    Mikie Moderator

    It's full of antioxidants. Many other foods are too if eaten raw. I also take antioxidants. I think it's important.

    Love, Mikie
  3. Jen102

    Jen102 New Member

    my first response was "well, duhhhh!" But then I suppose many docs would need a study to understand that we suffer from oxidative stress.

    Did you see someone's post last week--sorry I can't remember who posted it--related to a post about feeling toxic I think. It was about a researcher--was it James Robinson(?)--who said that several different antioxidants are required to scavenge the free radicals--that an antioxidant may take up the toxins and then pass them on to another antioxidant. The master endogenous antioxidant is glutathione, and it is often the last antioxidant in the chain before the toxin is excreted from the body. I have trouble producing or utilizing it. I have come back from the edge of death since getting glutathione iv's. I have felt like i was being slowly poisoned, 100 years old, and was near the end. I have made steady, baby step progress since getting this antioxidant. it is so interesting--and now the research says that we have oxidative stress. Goody, goody. When will it translate into an effective treatment? Sorry--getting fiesty. Jen102

    P.S. Oh, Martin Pall already concluded there is oxidative stress a few years ago but i suppose he isn't mainstream enough.
    [This Message was Edited on 11/15/2005]