Oxidative stress, TMJ disorder, and ME/CFS

Discussion in 'Fibromyalgia Main Forum' started by tansy, Oct 16, 2005.

  1. tansy

    tansy New Member

    CFSResearch.org » Chronic Fatigue Syndrome » The Journal of Chronic
    Fatigue Syndrome

    Journal of Chronic Fatigue Syndrome:
    Multidisciplinary Innovations in Research, Theory, and Clinical
    Practice
    Volume: 12 Issue: 3
    ISSN: 1057-3321 Pub Date: 10/5/2005
    Page Range: 45 - 61

    Association Between Oxidative Damage Markers and Self-Reported
    Temporomandibular Dysfunction Symptoms in Patients with Chronic
    Fatigue Syndrome

    Ross S. Richards PhD, Faculty of Health Sciences, Charles Sturt
    University, Albury, NSW, Australia
    Neil R. McGregor MDSc, PhD, Faculty of Dentistry,Bio21 Molecular
    Science and Biotechnology Institute, University of Sydney,
    University of Melbourne, Parkville, VIC, 3012, Australia,
    binrm@...
    Timothy K. Roberts PhD, School of Enviromental and Life Sciences,
    University of Newcastle, Callaghan, Australia

    The Journal of Chronic Fatigue Syndrome is © Copyrighted by The
    Haworth Press, Inc
    Reprinted with Expressed Permission of The Haworth Press, Inc

    ----------

    Abstract:

    Full blood counts, erythrocyte sedimentation rate (ESR), C-reactive
    protein (CRP), haematinics and markers for oxidative stress were
    measured on thirty-three patients diagnosed with chronic fatigue
    syndrome (CFS) and twenty-seven age and sex matched controls.

    The CFS patients had increased prevalence of symptoms of
    temporomandibular dysfunction (TMD). Jaw muscle pain was associated
    with increases in methaemoglobin (P < .002), ferritin (P < .02) and
    malondialdehyde (P < .007) whilst temporomandibular joint (tmj)
    clicking and/or locking was associated with increases in
    methaemoglobin (P < .001), malondialdehyde (P < .05) and vitamin B12
    (P < .02) levels.

    Multiple regression analysis found methaemoglobin to be the
    principle component associated with TMD symptoms in the CFS
    patients. Increases in scalar severity responses to jaw muscle pain
    and TMJ clicking and/or locking were positively correlated with
    methaemoglobin by multiple regression.

    These data indicate that oxidative stress due to excess free radical
    formation was associated with jaw muscle pain in CFS patients and
    suggest that these symptoms were likely to be associated with a
    pathogen-associated aetiology
  2. Rosiebud

    Rosiebud New Member

    I have a question on this and I've posted it on TANSY - help in case you dont come back to this post.

    Thanks.
    love
    Rosie