P450 - RICHVANK

Discussion in 'Fibromyalgia Main Forum' started by pawprints, Jun 27, 2008.

  1. pawprints

    pawprints New Member

    HI:

    Need some help on defining what this is? It keeps coming up in posts and for some reason I can't remember what it is.

    Is it a gene defect for detoxification?

    Also, how do we know we have it...what tests to determine it?

    I have stopped most of my Cowden protocal and am trying to decide on my next path. I think this is important for my decision making.

    I am stopping Cowden because it is so costly and time consuming but I did have results which I can't put into words...just feel different and ready to move ahead. Seems like Valcyte is not the way to go...may look into Cheney's program.

    Thank you to anyone who offers me insight.

    Shana
    P.S. I used to have a brain...but someone came and took it away!!! Just like the Bette Midler song says about Friends...those seemed to have left as well. Oh well, I still have this group. I am trying to remember that my glass is half full.
    [This Message was Edited on 06/28/2008]
  2. deliarose

    deliarose New Member

    I think this is one of the genes that is defective in some people. I believe Genova's Detoxigenomics panel screens for this.

    This is one of the tests that Rich Van K recommends.

  3. pawprints

    pawprints New Member

    Thanks. Does anyone know more about what this gene does and if a prescription is needed to get this test done?




    [This Message was Edited on 06/27/2008]
  4. richvank

    richvank New Member

    Hi, pawprints.

    The cytochrome P450 enzymes are a family of enzymes that perform Phase I detoxication on a variety of toxins and pharmaceutical drugs in the body, primarily in the liver, but also in some other organs. There are several different CYP450 enzyme isotypes. Examples are CYP 1B1, CYP3A4, CYP2C19, etc. There is some overlap in the toxins they handle, but each one specializes in certain toxins.

    Some people have polymorphisms (SNPs) in the genes that code for one or more of the CYP450 enzymes. These cause a decreased ability to detox the class of toxins that the enzymes deal with.

    The Genovations Detoxigenomic Profile examines eight of the CYP450 enzymes for SNPs, as well as several other enzymes used in the detox system. This profile does require a doctor's order. It used to cost in the neighborhood of $400, but I don't know what it costs now. Genovations leaves it up to the doctor how much you will be charged. They deal directly with the doctor.

    Having this profile run can be helpful in telling you what chemicals and drugs you should avoid, and it can also help to explain why you developed CFS. I think this is especially true in women, because many have a set of polymorphisms that result in additional oxidative stress when performing detox on the estrogens. At least, that's my hypothesis!

    Rich
  5. pawprints

    pawprints New Member

    HI:

    Thank you so much for the information. I am going to pull out my old tests this week and see if I had that test done. I assume my genes would not change. I am seriously considering pursuing Cheney's treatment either through him or another physician.

    I am wondering if I do have this gene defect whether it would block the protocal from working?

    You are such a great help!!! Thanks again for all you contribute.
    [This Message was Edited on 06/27/2008]
  6. pawprints

    pawprints New Member

    I checked and I did have the Genovations test done in 2003.

    I had polymorphisms on CYP1B1 and CYP2C9. The others you mentioned were considered without polymorphisms.

    I also checked the Yasko test and I have many double positives, especially COMT, ACE, SUOX and MAO A.

    Based on this and your knowledge of Cheney's new treatments, do you think I might be a succesful candidate?

    My current CFIDS specialist is encouraging me to go this route.

    Please give me any of your thoughts on this subject.

    Regards.
    [This Message was Edited on 06/28/2008]
  7. richvank

    richvank New Member

    Hi, pawprints,

    "I had polymorphisms on CYP1B1 and CYP2C9. The others you mentioned were considered without polymorphisms.

    I also checked the Yasko test and I have many double positives, especially COMT, ACE, SUOX and MAO A."

    ***I think the combination of polymorphisms on CYP1B1 and COMT is very interesting. Did you also have polymorphisms in GSTM1 and/or GSTP1? If so, my hypothesis for why women have a higher prevalence of CFS than do men would fit your case. I think that even having just the first two would bias you toward higher oxidative stress when metabolizing the estrogens.

    Based on this and your knowledge of Cheney's new treatments, do you think I might be a succesful candidate?

    My current CFIDS specialist is encouraging me to go this route.

    Please give me any of your thoughts on this subject.

    ***I might not be the right person to ask, because I have different views from Dr. Cheney's about what is going on in CFS. He has reported some improvement in the patients' condition with his approach, but I don't think it will bring about actual cures. I'm still hopeful that treatment that includes efforts to lift the methylation cycle block does have the potential for cure. You can find an update on it dated July 18,2007 in my list of posts.

    ***Rich

    Regards.