Parvo Virus Article

Discussion in 'Fibromyalgia Main Forum' started by kcollins, May 21, 2003.

  1. kcollins

    kcollins New Member

    Wow - most hopeful article on treatment of parvo virus induced CFS I've read (I got FMS in 1996 after parvo virus infection). Sounds like this doctor has successfully treated patients with an IV immunoglobbin (??). Copied article from this site's email bulletin below. Anyone know of a doc who treats patients this way?
    Take care,

    Parvovirus Infection and Chronic Fatigue Syndrome


    A wide variety of viral infections - enteroviruses, herpesviruses, hepatitis infections - have been implicated in precipitating Chronic Fatigue Syndrome (CFS)/ME. Among the less common causes is parvovirus B19 - an infection which is of growing interest to researchers as it can produce complications which include anaemia (the virus can replicate in the bone marrow), nerve damage (peripheral neuropathy and encephalitis), and miscarriage.
    Although parvovirus infection tends to affect small children (causing 'slapped cheek syndrome') it can also cause a febrile illness with a rash and widespread joint pains (especially in the small joints of the hands, knees, and ankles) in adults. And it's something (along with certain other infections and lupus/SLE) which should always be considered in the differential diagnostic assessment of an adult with ME/CFS who starts their illness with this type of infective picture followed by persisting joint pains in addition to fatigue. Blood tests, which detect virus-specific IgG and IgM antibodies, can help to confirm the diagnosis of parvovirus B19.

    Of equal importance is the fact that parvovirus B19-associated ME/CFS appears to respond to treatment. Using a form of immunological treatment known as intravenous immunoglobulin, doctors at London's Brompton Hospital have recently reported on the cases of three ME/CFS patients with parvovirus B19 infection who improved significantly after this form of treatment (400 mg/kg/day).

    There have also been several clinical trials reported involving the use of iv immunoglobulin in people with ME/CFS where no specific precipitating viral infection has been identified. However, the results have been conflicting and the role of iv immunoglobulin in treating non-parvovirus B19 ME/CFS remains the subject of debate.

    The doctors who treated the parvovirus B19 patients speculate that the treatment may work by helping to stabilize cytokine (immune system chemicals) dysregulation which occurs in response to acute and ongoing infections. The recovered patients also had evidence of a considerably reduced viral load (i.e., clearance of their viraemia) after treatment.

    Overall, these are interesting results which suggest that further assessment of immunoglobulin therapy in other sub-groups, where there is a clear post-infectious onset to ME/CFS, is warranted. This small but important study also emphasizes why I believe the MRC have got it so wrong when they conclude that research into causal factors (including the role of infection and the immunological response to infection) should not be given any high priority.

    Source: Clinical Infectious Diseases, 2003,36,E100-106

    NB: Other infections which can precipitate an arthralgia/joint pain and fatigue syndrome include brucellosis, leptospirosis, Lyme disease, and yersinia - some of which can be treated with drugs (ref: 'Living with ME', p41: 'The post-infectious arthralgia and myalgia fatigue syndrome').

    Dr. Charles Shepherd

    [This Message was Edited on 05/21/2003]
  2. skychomper

    skychomper Member

    Thanks for the info - I don't always check this site's info though I should. a recent test indicated I have parvo too, and the titers indicated a past infection. had cfs for 4 years now. my ex-doc said there was nothing I could do about the parvo. Are these IV drugs only for "active" infection, or does any positive test warrant this effort?
  3. kcollins

    kcollins New Member

    Thanks for responding - I also wondered if only for active infection......I don't know the answer. My doc also told me there was nothing that could be done about parvo virus - maybe this treatment is new or little known. Maybe someone else will come along who knows more.
  4. kcollins

    kcollins New Member

    Hi Ellie,
    I also developed FMS a month after my daughter had fifth disease. Luckily, the rheumatologist who I saw after being sick for 2 months was asking if anyone in family was sick when I got sick. I answered no - just me. Then he asked further if my kids had fifth disease when I got sick and I finally remembered my daugh. had a mild case before I got sick. The rheum. tested me for parvo and I was positive for active infection. Lot of good it did me though since there was no treatment according to the docs at the time. I'd be really interested to read your paper. Would you mind either pasting it on this board or email to me at:

    Take care,
  5. fifty1ford

    fifty1ford New Member

    This is amazing! Early on in my 18 month testing process I had tested positive for Parvo Virus B-19 and the Infectious Disease Doc. even had the test run a second time, with the same results. He was thinking that it was the cause of my problems, but none of the other "Specialists" that I saw concurred with his diagnosis. I've printed out the article and will show to my Doctor to see what she thinks of this.

    Maybe I shoud go back to the Infectious Disease Doc with this information. to see about possible treatments.

    Thanks for the valuable information.

    Peace and Well being to all,