Post Radiation Syndrome and a CFS like disease

Discussion in 'Fibromyalgia Main Forum' started by tansy, Aug 2, 2008.

  1. tansy

    tansy New Member

    Post-radiation syndrome as a NO/ONOO(-) cycle, chronic fatigue
    syndrome-like disease.

    Journal: Med Hypotheses. 2008 Jul 28.

    Author: Pall ML.

    Affiliation: School of Molecular Biosciences, Washington State
    University, Pullman, WA 99164-4234, USA.

    NLM Citation: PMID: 18667279

    Post-radiation syndrome is proposed to be chronic fatigue syndrome
    (CFS) or a chronic fatigue syndrome-like illness, initiated by
    exposure to ionizing radiation. This view is supported by the nitric
    oxide/peroxynitrite (NO/ONOO(-)) cycle mechanism, the putative
    etiologic mechanism for CFS and related illnesses.

    Ionizing radiation may initiate illness by increasing nitric oxide
    levels via increased activity of the transcription factor NF-kappaB
    and consequent increased synthesis of the inducible nitric oxide synthase.

    Two types of components of the nitric oxide/peroxynitrite cycle have
    been studied in post-radiation syndrome patients and shown to be
    elevated. The symptoms and signs of post-radiation syndrome and its
    chronicity are similar or identical to those of chronic fatigue
    syndrome and can be explained as being a consequence of nitric
    oxide/peroxynitrite cycle etiology.

    While the data available to test this view are limited, it provides
    for the first time a comprehensive explanation for post-radiation syndrome.
    [This Message was Edited on 08/02/2008]