There are some Dr's who believe that RA is caused by an infection, Proteus mirabilis or mycoplasma. Please show the following link about Proteus mirabilis infection to your niece's family...and also the other links have some very good info. http://www.ncbi.nlm.nih.gov/pubmed/23992372 Great info from Dr Mercola about treatment with antibiotics: http://articles.mercola.com/sites/articles/archive/2010/08/16/rheumatoid-arthritis-protocol.aspx Gluten can also play a big role. There are lots of good articles here: http://www.naturalnews.com/GoogleSe...rl=www.naturalnews.com/&ref=&ss=1662j360152j9 I wonder if she would benefit from curcumin more than a pharmaceutical drug... Doctors really don't know about supplements, herbs, etc. Thanks for the update, Patti. I will continue prayers for your niece.