Prefontal cortex oxygenation, exercise and ME/CFS

Discussion in 'Fibromyalgia Main Forum' started by tansy, Aug 2, 2008.

  1. tansy

    tansy New Member

    Prefrontal cortex oxygenation during incremental exercise in chronic
    fatigue syndrome.

    Journal: Clin Physiol Funct Imaging. 2008 Jul 29. [Epub ahead of print]

    Authors: J. Patrick Neary [1], Andy D. W. Roberts [2], Nina Leavins
    [2], Michael F. Harrison [1], James C. Croll [2] and James R. Sexsmith [2]

    [1] Faculty of Kinesiology & Health Studies, University of Regina,
    Regina, SK, Canada and

    [2] Faculty of Kinesiology, University of New Brunswick, Fredericton NB, Canada

    Correspondence to J. Patrick Neary, PhD, Faculty of Kinesiology &
    Health Studies, University of Regina, Regina, SK, Canada S4S 0A2

    Affiliation: Faculty of Kinesiology & Health Studies, University of
    Regina, Regina, SK, Canada.

    NLM Citation: PMID: 18671793

    This study examined the effects of maximal incremental exercise on
    cerebral oxygenation in chronic fatigue syndrome (CFS) subjects.
    Furthermore, we tested the hypothesis that CFS subjects have a
    reduced oxygen delivery to the brain during exercise.

    Six female CFS and eight control (CON) subjects (similar in height,
    weight, body mass index and physical activity level) performed an
    incremental cycle ergometer test to exhaustion, while changes in
    cerebral oxy-haemoglobin (HbO(2)), deoxy-haemoglobin (HHb), total
    blood volume (tHb = HbO(2) + HHb) and O(2) saturation [tissue
    oxygenation index (TOI), %)] was monitored in the left prefrontal
    lobe using a near-infrared spectrophotometer. Heart rate (HR) and
    rating of perceived exertion (RPE) were recorded at each workload
    throughout the test.

    Predicted VO(2peak) in CFS (1331 +/- 377 ml) subjects was
    significantly (P </= 0.05) lower than the CON group (1990 +/- 332
    ml), and CFS subjects achieved volitional exhaustion significantly
    faster (CFS: 351 +/- 224 s; CON: 715 +/- 176 s) at a lower power
    output (CFS: 100 +/- 39 W; CON: 163 +/- 34 W). CFS subjects also
    exhibited a significantly lower maximum HR (CFS: 154 +/- 13 bpm; CON:
    186 +/- 11 bpm) and consistently reported a higher RPE at the same
    absolute workload when compared with CON subjects. Prefrontal cortex
    HbO(2), HHb and tHb were significantly lower at maximal exercise in
    CFS versus CON, as was TOI during exercise and recovery.

    The CFS
    subjects exhibited significant exercise intolerance and reduced
    prefrontal oxygenation and tHb response when compared with CON subjects.

    These data suggest that the altered cerebral oxygenation and blood
    volume may contribute to the reduced exercise load in CFS, and
    supports the contention that CFS, in part, is mediated centrally.

    central fatigue • cerebral oxygenation • chronic fatigue syndrome •
    exercise • near-infrared spectroscopy
  2. cct

    cct Member

    Thanks for the post!

    It is encouraging to know that someone is looking at oxygen and exercise fatigue in people with CFS.

    I really appriciate your efforts in keeping us up to date on the latest research.

  3. Waynesrhythm

    Waynesrhythm Member

    Hi Tansy,

    I've long felt that somewhere along the pathway to ME/CFS, our oxygen utlization mechanisms became compromised for many of us. So the results of this study do not surprise me at all. It's nice to see it documented.

    I mentioned on my <a href="">MMS experimentation thread</a>, that one of the first improvements I noticed was a sense of significantly improved oxygen utilization. And this was at the very beginning when I was around 1/3 drop every other day. I think some of my subsequent incremental improvements are a result of having more oxygen available in my body.

    I followed up recently on a recommendation by Rainbow11 and started taking a product called Cell Food which is supposed to also increase oxygen availability in the body. I only take one drop at a time, and so far always feel a lift after taking it. Whether this is from increased oxygen or not, I can't say. The store I bought it from said the sell a lot of it, with some customers saying it's very effective for altitude sickness. Lots of mountains here in Oregon.

    Thanks for posting this information.

    Regards, Wayne
    [This Message was Edited on 08/02/2008]
  4. DeborahLynn

    DeborahLynn Member

    Thanks for posting this!

  5. mezombie

    mezombie Member

    This should put to rest the incorrect assumption that aerobic exercise is "good for us".

    [This Message was Edited on 08/03/2008]
  6. getwellgirl

    getwellgirl New Member

    I would just like to point out that if one's thyroid and/or adrenals are working as they should which is known to happen because of a central problem with the HPA axis then this would cause an oxygen defect in the brain and body.

    Taking supplemental active hormines like cortisol, T4 and T3 really helps and allow me to exercise the majority of days though not to pre-CFS/ME levels.

  7. mbofov

    mbofov Active Member

    Thanks for posting - one more brick in the wall --

  8. Waynesrhythm

    Waynesrhythm Member

    Hi Pam,

    Thanks for sharing this information. I've done a fair amount of research on thyroid and adrenal function and don't recall reading about their connection to oxygen utilization. Very good information. Thanks.

    Regards, Wayne
  9. tansy

    tansy New Member

    Hi Wayne

    Many of us know we have poor oxygen utilisation. Being in a room with low oxygen levels adversely affects me; whilst being out of doors where the air quality is good has a good effect on me.

    Haematoligists commented on oxygen levels and two different types of muscles tests showed perfusion.

    I've been following your posts on MMS and have been fascinated by your response to even a tiny dose. I hope MMS continues to help you reduce the severity of some of your symptoms.

    tc, Tansy