Pregabalin & Milnacipran for FMS

Discussion in 'Fibromyalgia Main Forum' started by kmelodyg, Aug 4, 2003.

  1. kmelodyg

    kmelodyg New Member

    HELP IS ON THE WAY: Two drugs that may relieve the symptoms of fibromyalgia are
    expected to
    enter phase III clinical trials this year. Patients treated with pregabalin and
    milnacipran in early trials reported significant improvements in pain and
    fatigue. Philip Mease, M.D., chief of rheumatology clinical research at Swedish
    Hospital Medical Center in Seattle, has worked on both studies. He says both
    medications are restoring unbalanced neurochemicals in the brain to a more
    natural balance.

    PREGABALIN: Of 529 patients in phase II of the pregabalin study, 29 percent of
    treated patients
    reported at least a 50-percent reduction in pain compared to a 13-percent
    reduction in patients who were given a placebo. The drug also improved sleep
    quality in patients. The most common side
    effects were mild dizziness, which went away as drug use continued. Pregabalin
    is being studied as a treatment for seizures and neuropathy also. The drug could
    be approved next year. 

    MILNACIPRAN: In phase II of the milnacipran study involving 95 patients, 87
    percent of treated
    patients reported improvement compared to 33 percent in the placebo group. About
    36 percent of
    treated patients reported at least a 50-percent reduction in pain intensity
    compared to 9 percent of patients who were treated with a placebo. Patients also
    showed improvements in depressed mood.
    One side effect in the milnacipran study was nausea. The drug will likely be
    approved in two years.

    Milnacipran is already approved in other countries, including France and Japan,
    as an anti-
    depressant. More than 1 million people have used the drug.

    Dr. Mease says fibromyalgia has been a difficult condition to treat but new
    research is promising. He adds, "Now that the medical community is taking
    fibromyalgia more seriously because of biological understanding, companies are
    now willing to put in resources to find ways to help."


    Cypress Pharmaceutical, Inc.

    [This Message was Edited on 08/04/2003]