I've CFIDS for a long time now, and I do and take a bunch of different things to improve my health, but I had a recent reminder of just how important one of those things is. I accidentally decreased my dose of pregnenolone, and I became basically non-functional again. Not only did I have zero energy, but I was completely depressed as well. It might not be necessary for everyone, but please have your levels checked and address low levels if need be. I've found that there is a narrow window between too little and too much of this stuff, so I would recommend starting low (like 1mg) and slowly working up. Also, there is a physiological justification for why pregnenolone levels are so low in people with CFIDS: "Although the energy crisis and associated hypothalamic dysfunction, along with direct gland failure (e.g., low thyroid adrenal exhaustion) explained most of the abnormalities we see in CFS and fibromyalgia, there have been a few missing pieces over the years that were not explained by these - which frankly left us puzzled. Here are a couple items I've scratched my head over in CFS: Very low cholesterol levels are often seen in CFS (sometimes high levels are seen, but these are usually due to low thyroid function). Dramatically low levels of a hormone called pregnenolone (made from cholesterol, pregnenolone is the critical building block for steroid hormones such as estrogen and testosterone). This new study now explains why cholesterol and pregnenolone are sometimes very low in CFS. Viral infections cause your body to make interferon, which suppresses the mevalonic acid pathway that makes cholesterol and pregnenolone. This is likely another key reason - along with the hypothalamic dysfunction, gland dysfunction and receptor resistance - for the widespread hormonal disorders we see in CFS/FMS. This finding is significant in that it not only suggests that low cholesterol or pregnenolone in CFS may be caused by a viral infection, it also suggests new possible treatments!"