Proanthocyanidin

Discussion in 'Fibromyalgia Main Forum' started by selma, Apr 18, 2003.

  1. selma

    selma New Member

    I went to Proanthocyanidin on a search on Google.
    The second article by Anne Marie Fine is the article that I'm writing about. On page three is the Theraputic Applications. I don't know if it's too much info for here to read, but I'll post it.
    Therapeutic Applications

    Free radical damage has been strongly associated with virtually every chronic degenerative disease, including cardiovascular disease, arthritis, and cancer. Free radicals are highly reactive and cause tissue damage by reacting with polyunsaturated fatty acids found in cellular membranes, nucleotides in DNA, and sulfhydryl bonds in proteins. Free radicals may originate endogenously through normal metabolism and exogenously from polluted air, solvent-laden water, pesticide-laced food, or radiation exposure.

    Clearly, due to their antioxidant activity, the therapeutic potential of proanthocyanidins is quite broad. In Europe, proanthocyanidins are used mainly for the treatment of vascular disorders such as venous insufficiency, varicose veins, and microvascular problems including capillary fragility and retinopathies.1 In fact, proanthocyanidins are the active ingredient in a proprietary pharmaceutical product sold in France (Endotelon) used primarily for microcirculatory disorders. The main features of proanthocyanidins that comprise the rationale for use in vascular disorders have been demonstrated experimentally:1

    - Specificity for the hydroxyl free radical

    - Traps lipid peroxides and free radicals

    - Markedly delays the onset of lipid peroxidation

    - Chelates to free iron molecules, so as to inhibit iron-induced lipid peroxidation

    - Non-competitively inhibiting xanthine oxidase, a major generator of free radicals

    - Inhibits hyaluronidase, elastase and collagenase, which can degrade connective tissue structures and lead to increased permeability

    Proanthocyanidins have garnered recent attention in helping to explain the "French Paradox," the observation in France that high intake of dietary fats does not necessarily lead to high rates of atherosclerosis and coronary heart disease. When this paradox first came to light, research focused on the consumption of alcohol in the form of red wine as the preventive factor, but these results were equivocal.8 Further research revealed that phenolic substances in red wine, including proanthocyanidins, had potent antioxidant properties, reducing the oxidation of human LDL in vitro, as well as inhibiting cyclooxygenase and lipoxygenase of platelets and macrophages in vivo, further reducing thrombotic predisposition.8

    The 1998 Tufts University, "Dietary Antioxidant and Human Health Conference," highlighted the results of new research on proanthocyanidins and has been the most comprehensive scientific review of polyphenols in the United States to date. At this conference, Dr. Morazzoni, scientific director of Indena S.p.A., reviewed epidemiological studies that suggested grape polyphenols, present in red wine among other sources, could prevent the development of chronic vascular disease such as atherosclerosis. His conclusion was, "Grape procyanidins are a viable and clinically-proven, bio-active antioxidant for the prevention of cardiovascular diseases."

    Dr. Kendall, from the University of Birmingham in England, also introduced results from his clinical research using standardized grape seed extract. His study demonstrated measurable changes in serum antioxidant activity in the patients receiving the extract, leading him to conclude antioxidants may play a role in sudden death prevention, referring to the fact that for many patients with coronary artery disease, sudden death may be the first and only indication of the disease.15

    Other noteworthy research in this area, almost exclusively conducted in Europe, includes:

    1. Oral administration of procyanidins from grape seed produced a hypo-cholesterolemic effect in a high-cholesterol animal feed model. Specifically it prevented an increase in total and LDL plasma cholesterol and a decrease in HDL.16

    2. In a different hypercholesterolemic model, OPCs significantly lowered the amounts of cholesterol bound to aortic elastin compared to controls.17

    3. Oral administration of OPCs in an experimental model effectively increased natural killer cell cytotoxicity and modulated ex vivo levels of interleukin-1, interleukin-6, and interleukin-10 in immune-compromised animals.18

    4. OPCs from grape seed demonstrated in vitro antimutagenic activity.19

    5. In a double-blind study, 71 patients with peripheral venous insufficiency received 300 mg OPCs from grape seed per day. A significant reduction in functional symptomatology was observed in 75 percent of the treated patients compared to 41 percent of the patients given a placebo.20 6. Measurements confirmed that a single administration of 150 mg OPCs increased venous tone in patients with widespread varicose veins.21

    7. In a double-blind clinical trial, a group of elderly patients with either spontaneous or drug-induced low capillary resistance were treated with 100-150 mg OPCs from grape seed extract per day or placebo. Fifty-three percent of patients in the treated group demonstrated noticeable improvement in capillary resistance after approximately two weeks. All patients in this group reached the maximum attainable result after three weeks.22

    8. In an open trial, 147 retinopathy patients received 100 mg OPCs from grape seed per day. The OPCs successfully treated exudations secondary to hypoxia of a diabetic, inflammatory, and arteriosclerotic nature.23

    9. In a placebo-controlled clinical trial of 63 female breast cancer patients, post-surgical edema of the upper extremities was tested using 300 mg per day OPCs in the treated group for six months. At six months the OPC-treated group's functional score was significantly improved. In particular, there was a disappearance of pain in 59 percent of the treated patients compared to 13 percent taking the placebo.24



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    Conclusion

    Oligomeric proanthocyanidin complexes are primarily known for their free radical scavenging and antioxidant activity. However, these compounds have also been reported to demonstrate antibacterial, antiviral, anticarcinogenic, anti-inflammatory, anti-allergic and vasodilatory actions. In addition, OPCs have been reported to inhibit lipid peroxidation, platelet aggregation, capillary permeability and fragility, and to affect enzyme systems including phospholipase A2, cyclooxygenase, and lipoxygenase. These varied biological activities have resulted in the phytopharmaceutical application of OPCs in reduction of edema, increased peripheral circulation, improvement in vision, treatment of diabetic retinopathy, prevention of cardiovascular disease, treatment of hypercholesterolemia, stabilization of connective tissue tone, reduced adverse allergic and inflammatory responses, and enhanced immune function and wound healing. Additional clinical research is warranted.
    The references and history are informative too.
    Good Luck. Selma


    [This Message was Edited on 04/18/2003]
  2. selma

    selma New Member

    Has anyone taken this for 6mos?
  3. selma

    selma New Member

    My swollen hands are getting better during the day. Even after typing now. Hope it works for You.
    I'm also going to try the OLE (Olive leaf extract ).
    I'll let you know if the swelling goes down.
    Also trying Mindfullness Meditation-Zinn.
    Love to all, Selma