I did a search and found a few people that started on this supplement many, many years ago. Since it is supposed to increase Glutathione in the cells by almost 400 percent I would think lots of people would have tried it. I cant really find any recent posts from people with CFS though. If indeed CFS has an Oxidative Stress component and Glutathione deficiencies as a major contributor according to some CFS professionals, I would think this would have been looked at. Either it was given the thumbs up or thumbs down??? I appreciate all input but am really looking for people who have tried it or truly understand what a Nrf 2 activator is. Rich would be great in this regard. Thank you!