Hi All, I've been taking zoloft for about 12 years now and it is just not working anymore!!! I've tried all of the newer anti-depressants: cymbalta, effexor, wellbutrin, etc.... Basically, the only one that I haven't tried yet is Prozac. Just wondering if anyone has had better results with prozac than zoloft. After all of my horrible experiences with most anti-depressants, I am scared to switch but my depression is taking over my life!!!!!