Have seen a few threads about the dual reuptake inhibitors and thought i would let you guys know how i have been doing on reboxetine (just a noradrenaline reuptake inhibitor). Have been on it for 3-4 weeks, and only take it once a day as i didnt want it to interfere with my sleep and then adjust it from there. I started on 1/2 tab (2mg) in the morn and the first few days had good increases in energy, side effects were increased sweating, the sweating has subsided and have good energy (not over stimulated) and concentration, no weight gain or increase in apettite. Have also found it helps a little with nerve type pain like pins and needles, hot/cold prickly feeling that i sometimes get in my back muscles. Overall it has been good and havent found the need to increase the dose and besides the first few days, it doesnt effect my sleep. I am sensitive to AD's ssri's and can only tolerate low doses like 1/4 tab zoloft and found it didnt really help anyway. Hope this helps someone out there, worth a try. Has been good for me in combo with antivirals and lyrica/zopiclone combo for sleep.