RELAPSING BORRELIOSIS- Brain appears to be reservoir

Discussion in 'Lyme Disease Archives' started by victoria, Aug 7, 2006.

  1. victoria

    victoria New Member

    I don't know if this particular variant of the lyme spirochete (lyme) is present in N. America, but I wouldn't doubt that other varieties could be capable of this...

    and would certainly explain a lot for many people with 'autoimmune diseases' and relapsing symptoms of CF/FM etc....

    (words in all caps are mine, for emphasis)

    Persistent Brain Infection and Disease Reactivation in Relapsing Fever Borreliosis

    Christer Larssona, Marie Anderssona, Jenni Pelkonenb, Betty P. Guoa, Annika Nordstranda and Sven Bergströma, aDepartment of Molecular Biology, Umeå University, SE-901 87 Umeå, Sweden bDepartment of Medical Microbiology, Turku University, Turku, Finland

    Received 19 January 2006; accepted 20 April 2006. Available online 30 May 2006.


    Relapsing fever, an infection caused by Borrelia spirochetes, is generally considered a transient, self-limiting disease in humans.

    The present study reveals that murine infection by Borrelia duttonii can be reactivated after an extended time as a SILENT infection in the brain, with NO BACTERIA APPEARING IN THE BLOOD and spirochete load comparable to the numbers in an infected tick.

    The host cerebral gene expression pattern is INDISTINGUISHABLE FROM THAT OF UNINFECTED ANIMALS, indicating that persistent bacteria are NOT recognized by the immune system nor cause noticeable tissue damage. SILENT INFECTION CAN BE REACTIVATED BY IMMUNOSUPPRESSION, inducing spirochetemia comparable to that of initial densities.

    B. duttonii has never been found in any host except man and the tick vector. We therefore propose the brain to be a possible natural reservoir of the spirochete. The view of relapsing fever as an acute disease should be extended to include in some cases prolonged persistence, a feature characteristic of the related spirochetal infections Lyme disease and syphilis.

    If this werre a murder mystery...

    I'd say "the plot thickens..."

    [This Message was Edited on 08/08/2006]

    ANNXYZ New Member

    It seems that there is SOOO much that is still unknown about this bacteria , which explains why treatment is a hit or misss effort in each case .