Ribose for pain

Discussion in 'Fibromyalgia Main Forum' started by tansy, Oct 26, 2005.

  1. tansy

    tansy New Member

    Treat Pain With Sugar
    By Vivian Richardson, Ivanhoe Health Correspondent

    (Ivanhoe Newswire) -- A little sugar can help reduce chronic pain. No, this isn't the sugar you'll find in ice cream or soda pop, but it does have a sweet effect on pain conditions like fibromyalgia.

    Researchers at the Annapolis Research Center for Effective CFS/Fibromyalgia Therapies tested how effective a certain kind of sugar would be at reducing chronic pain. The treatment goes along with the idea that treating the source of pain is more effective than masking the pain.

    Jacob Teitelbaum, M.D., is the lead researcher for the study. He likens pain to the oil light on a car dashboard. When the oil light flashes red, we know the car is low on oil. Human pain is analogous to that light. "But, unfortunately, there is nothing written on it," Dr. Teitelbaum says. "Pain is a way of saying something desperately needs attention, whether it's a thorn in your foot or your hands on a hot stove."

    Dr. Teitelbaum believes one not-so-obvious factor of painful conditions, like fibromyalgia, may be an energy crisis in the body's cells. That's where the sugar ribose comes in. Ribose is used by the cell's power-generators, mitochondria, to make energy molecules for the body. Ribose is actually one component of DNA (deoxyribonucleic acid). The body creates the sugar, however, some people are not able to create enough of their own ribose -- leading to less energy and more pain.

    Dr. Teitelbaum and his team tested a ribose supplement on 40 patients with fibromyalgia and/or chronic fatigue syndrome. Each patient was given a 5-gram scoop of ribose, usually dissolved in water, three times a day. Later in the study, patients could opt to reduce the dosage to two times per day.

    Preliminary results of the study show about two-thirds of the subjects reported increased energy and decreased pain. Researchers report 20 percent had a dramatic improvement in their pain levels. The average improvement in pain for all the patients was about 25 percent.

    Dr. Teitelbaum says these results point to what may be one treatment that can be added to the regimen of relief for chronic pain sufferers. "This is one piece of the puzzle. It helps with the nutritional support," he says.

    The next step for this research team is to design a larger, double blind study.

    SOURCE: Ivanhoe interview with Jacob Teitelbaum, M.D., Medical Director, Annapolis Research Center For Effective CFS/Fibromyalgia (FMS) Therapies
  2. jess

    jess New Member

    Hi Tansy, I have been using D ribose along with coq10, magnesium and carnitine for several weeks now. I am using it for diastolic dysfunction. It has definitely helped improve the palpitations. However, my fasting blood glucose levels have increased to 103. Normal should be under 100 or even less. I was wondering if this is from the ribose. Of course my Doctor has no idea. It does say on the container of ribose caution for diabetics which I am not. I can't seem to find much on whether it can raise glucose levels. Do you have any ideas? Thanks so much you always have such great info for us. Jess
  3. maris

    maris New Member

    Hi Tansy,
    I tried ribose for about a week. At first it gave me a weird kind of energy, then nothing at all.

    I tried upping the dose, but it had no pain relieving effects what so ever. Perhaps I didn't use it long enough.
    I still have half a bottle in the cabinet.

    Try doing a search on it. If I recall, others on this board have tried it with little results.

    Maris


  4. tansy

    tansy New Member

    Hi Jess

    Below is some information on ribose, it can affect blood sugar levels, so maybe either this is not for you or you need to start on a very low dose and build it up judging your dose by how things go.

    A Breakthrough in Energy Production: D-Ribose
    By Dr Edward Conley

    D-Ribose is a natural pentose sugar and is a structural component of
    DNA, RNA, ATP, and other important nucleotides found in all living
    cells. What is a pentose sugar? Most of you are familiar with 6
    carbon sugars: Sucrose (table sugar), fructose (fruit sugar) etc.

    Ribose has 5 carbons and is formed naturally within the body via the
    pentose phosphate pathway (the pentose phosphate pathway converts 6
    carbon sugars to 5 carbon sugar (ribose) which increases the ATP
    within muscles (including heart and skeletal muscle). In the body
    this pathway is very slow and not very efficient in heart and
    skeletal muscle due to low concentrations of the necesary enzymes
    (like glucose-6-phosphate dehydrogenase G6PD) On top of that it is
    estimated that over 100 million people worldwide have G6PD
    deficiency! (This means that they have a very difficult time making
    Ribose).

    Most of the people with G6PD deficiency live in Southern
    Europe or Northern Africa. This deficiency was originally developed
    to help people fight malaria. I know this is a little complicated
    but stick with me here....this is really important! Why is this
    important to you? Many of you are of Southern European or North
    African heritage. Even if you don't think you are you could still
    have G6PD deficiency (as an example G6PD deficiency is found in some
    people of Irish heritage...why do some of the Irish have an
    inherited gene to help them fight malaria?

    The Moors (who were from
    North Africa) invaded and occupied southern Ireland for nearly 300
    years. That is more than likely how this trait wound up in Ireland,
    England, Spain and elsewhere in Northern Europe and therefore in us,
    since many of us are from Northern European heritage.)

    Long and short of it: We don't make Ribose very easily under optimal
    conditions and if you have G6PD deficiency you have a very difficult
    time making Ribose at all! The less Ribose the more difficult it is
    for you to make ATP. As all of you know the more ATP you have the
    more energy you have. Higher levels of ATP improves brain function,
    muscle strength and endurance (including the heart), and strengthens
    immunity. The more ATP you have the slower you age, since aging is
    to a great degree the loss of ability to make ATP in the
    mitochondria...which results in lower function of the cell and
    eventually cell death.

    Nearly everyone with CFIDS/FM have lower
    levels of ATP as compared with "normal" people their age. I have
    worked for over 20 years to improve the Krebs cycle (energy
    producing machinery) for PWC's and PWF's. What we didn't know is
    that Ribose is vital to making ATP in the cells, especially muscle
    cells and that so many people have such a hard time making this
    important nutrient. As we age, we make ribose more poorly, if we
    have any form of G6PD deficiency we have very low ribose levels,
    illness or ischemia lowers ribose levels further. (I will explain a
    little later the studies that show how important ribose is to heart
    function).

    How does ATP work?

    It works rather like an hydroelectric
    generator. We store ATP on one side of the mitochondrial membrane
    (like we store water on one side of the dam) then as the ATP passes
    through the membrane it turns a turbine rather like the turbine
    inside the dam. The more ATP you build up on one side the more
    energy you create.

    How To Make More Ribose and More Energy

    We do not know how to improve how the body makes ribose from regular
    sugar. The exciting development is that by supplementing ribose you
    can increase the amount of ribose inside the muscle cell and
    therefore improve the cells ability to make ATP! The more ATP your
    muscles make the better you feel...less fatigue, less pain, less
    muscle weakness and faster recovery time! How do measure if you are
    low in ribose? We can't..there isn't a commercial test available to
    determine if you are low in ribose...so for most people we have to
    give a clinical trial.

    How to take Ribose

    D-Ribose given orally is rapidly absorbed from the gut in about 30-
    45 minutes. It is well absorbed into muscle and then is changed
    inside the muscle to ribose-5-phosphate. Ribose not taken up by
    muscle is excreted in the urine. Many people have noticed improved
    energy within one week of use although we usually recommend a one
    jar trial (about a month). Many people with CFIDS or FM notice
    improvement within an hour. Heart problems require treatment a
    little longer.

    Usual dosage is 5 Grams twice daily taken with meals.
    A third serving may be added if neceasary. I change the timing of
    the dose in PWC's to twice a day...with one dose before activity or
    exercise. Ribose can be dissolved in water, juice, milk or sprinkled
    over cold foods of choice. It has a sweet taste like sugar and
    generally has very low side effects. If you are an insulin dependent
    diabetic, consult your doctor prior to using ribose. Pregnant women
    should not use ribose.

    Mild, transient hyopglycemia has been
    reported since ribose may down-regulate a liver enzyme responsible
    for glycogen mobilization...so far none of my patients with
    hypoglycemia have reported any adverse events. If you know anyone
    with Cardiomyopathy, or serious Coronary Artery Disease, Congestive
    Heart Failure or fatigue post cardiac by-pass surgery they should
    consider a trail of ribose.

    It is my opinion
    that everyone with CFIDS or Fibromyalgia should give ribose a one
    month trial. Ribose begins it's jouney as corn.... however the
    manufacturer has not had any allergic symptoms reported. Several of
    my patients who are allergic to corn have tolerated ribose well
    since most of the corn protein is gone. That having been said if you
    are allergic to corn you should monitor how you feel the first week
    to make sure you do not have any symptoms (and start at a much lower
    dose and build up slowly) If corn has caused you shortness of breath
    or tightness in the throat in the past then I would avoid ribose.[This Message was Edited on 11/03/2005]
  5. tansy

    tansy New Member

    have an ATP test, this can be ordered through Dr Sarah Myhill's office even if you are not one of her patients. A number of UK doctors treating PWME/CFS (outside the NHS) use Biolab.

    Many PWME/CFS are having their mitochondrial/ATP issues confirmed through Biolab; the problem is cellular and cannot be fixed through CBT, graded exercise, or antidepressants! You can read more about this test on Biolab's and Dr Myhill's web sites.

    Tansy[This Message was Edited on 11/03/2005]
  6. dancingstar

    dancingstar New Member

    I was taking it for a few weeks was feeling great until I ran out of it for a couple of days...and I started to feel bad. Yesterday I felt horrid, hurt everywhere all day long.

    Started to take it again today, and sure enough, I'm beginning to feel better again. No question in my mind that the stuff is working for me. I won't stop taking it for quite some time now.

    I can think more clearly, don't really hurt while I'm taking it, just feel healthier. It doesn't give me more energy, just makes me feel better so that I can get more done.

    I felt it instantly...twice now. Unfortunately or fortunately, whatever, I even feel a difference in my heart...so very strange to me. This one is a keeper as far as I'm concerned.