Rich and others ! Possible new, natural retro viral treatment ?

Discussion in 'Fibromyalgia and ME & Chronic Fatigue Syndrome' started by karinaxx, Sep 20, 2010.

  1. karinaxx

    karinaxx New Member

    I am looking into natural retro viral therapies ( mainly Ayurveda, because i live in India).
    This one, not Aryuveda, seemed to me very promising because it seems to cover so many of the issues we face with ME/CFS .
    I would be interested if any one nows about this herb and has used it ? From the science folks here , i liked to know what they think.
    ( I heard much about the search for natural remedies in the Amazon, but never looked into it, since i live in India and know more about Ayurveda)

    Croton lechleri

    Use: It shows strong antibacterial, anti-microbial, antiviral, antileukemic, anti-mycotic, anticancerous, anti-itch, antiulcerous, antihemorrhagic, antioxidant, and haemostatic effects. It speeds up healing of the wounds, tissues, skin, thrushes, ulcers, and inflammations, mainly in oral cavity, pharynx, and larynx, and other areas. It has also strong anti-stress, aphrodisiac, and tonifying effect. It facilitates regeneration and strengthens the immunity of the organism. It positively affects the cases of respiratory and pyretic conditions, influenza, malaria, hepatitis A and B, diseases caused by the retroviruses, cytomegaloviruses, and other infectious diseases, activates bone marrow, Herpes, Flu A&B, PIV, RSV, HIV, stomach & peptic ulcers, Parkinson disease, CNS disorders, Lyme borreliosis, multiple sclerosis, anemia, cancer, Leukemia. trigeminal nerve inflammation, flatulence, digestion disorders, diabetes, diarrhea, arthrosis & cervical and dorsal spine conditions, multiple sclerosis. Drags Imun affects the channels of spleen, stomach, three burners, small and large intestines, and yang and yin connective channels.

    Drags imun (SANGRE DE DRAGO – Dragon's Blood ) is a bio-information preparation based on the combination of the principles of the latest findings in the fields of plant therapy, homeopathy, crystal therapy, bio-resonance, psychotronics and the principles of traditional Chinese medicine. Drags imun contain a pure latex from the tree Croton lechleri Muell. Arg. Peruvian Indians call this tree SANGRE DE DRAGO – Dragon's Blood. Latex is of red color and is collected by cutting the bark of the trees that could be found along the rivers in the Peruvian Amazonia.

    Product characteristics: bio-information preparation
    Content: 30 ml (30 ml of Energy product equals 400 ml/14 oz of a typical extract)




    General Research:

    From the therapeutic point of view Croton lechleri used topically inhibits gram-positive bacteria and dermatophytic fungi. It acts on Sindbis virus, Cytomegalovirus murine, and Escherichia coli. Trimethoxyphenols obtained from Croton lechleri have stronger effect than the effect of penicillin. The mixture of proanthocyanidin polymers known as SP-303 shows stronger properties inhibiting the strains of respiratory syncytial viruses (RSV) A and B, influenza A (FLU-A) and parainfluenza viruses (PIV).


    Further it inhibits Herpes simplex virus (HSV), including the one unresponsive to acyclovir and foscarnet. It is also effective against Hepatitis A and B viruses. One of the latest discoveries (Miller M., 1999) has shown the activity of Croton in vitro against Helicobacter pylori that cause stomach ulcers. The tests proved that in cases of peptic ulcers it speeds up the healing by almost 50% and it improves also quality of a stomach wall. In low concentrations Croton lechleri has prooxidant effect and in high concentrations it has strong antioxidant effect.


    This tree contains two types of alkaloids with stimulating and relaxing effect; 54% of tannin that has strong astringent effect; 4% of sugar composed of milk sugar, galactose, and rhamnose; further phenolic compounds – among them gallic acid and saponins of low concentrations; taspine chlorhydrate, -3',4-O-dimetylocedrusine, and proanthocyanidin; six simple phenols and their derivatives, three steroids (sitosterol, b-sitosterol, and catechins). Six diterpenoids and SP – 303 oligomeric proanthocyanidin were found in the tree bark.

    Croton lechleri shows strong antibacterial, anti-microbial, antiviral, anti-mycotic, antioxidant, and haemostatic effects, which speed up healing of the wounds, tissues, skin, thrushes, ulcers, and inflammation, mainly in oral cavity, pharynx, and larynx.

    It has also strong anti-stress, aphrodisiac, and tonifying effect. It facilitates regeneration and strengthens the immunity of the organism. It positively affects the cases of respiratory and pyretic conditions, influenza, malaria, hepatitis A and B, diseases caused by the retroviruses, cytomegaloviruses, and other infectious diseases.

    Drags Imun primarily affects the channels of spleen, stomach, three burners, small and large intestines, and yang and yin connective channels . Thus it affects the conditions related to the insufficient function of the organs on the aforementioned channels.

    Spleen and its importance:

    The cases of malfunction of spleen, which is the important organ for immunity, may cause various problems. The extremities lose their power and mobility (primarily toes), the muscles slacken and the atrophy occurs. This condition is accompanied by the aches and pain in the area of ribs, middle and cervical spine. The lips are pale and droopy and one loses one's appetite. The secretion of saliva is increased. In some cases saliva may spontaneously ooze out of the mouth. When the channels of spleen and heart are in disorder, it causes deterioration of the brain and other mental conditions. If it is accompanied by the stress, then it results in digestion disorders, loss of appetite, flatulence, sometimes even vertigo, vomiting, heart pounding, swellings, and others.

    Drags imun as Alternative medicine:

    The preparation activates bone marrow and shows a positive effect the regeneration of blood in cases of anemia and leukemia . It improves functioning of the lungs and heart , quality of bones and joints , and has positive effect in cases of arthrosis and cervical and dorsal spine conditions.

    Drags imun combined with Renol, Vitamarin, and Artrin cream earned name "arthritis medicine natural rheumatoid" from people who already tried it themselves.

    In dentistry it may be used in the treatment of periodontitis, bleeding gums , increased decay of teeth , and post-extraction conditions.

    It protects the genetic information of cells from damage, and acts in cases of decreased function of thyroid gland , Parkinson disease , trigeminal nerve inflammation, the CNS disorders, Lyme borreliosis, varicose and stomach ulcers , inflammations of small and large intestine, diarrhea, flatulence, digestion disorders, diabetes, and multiple sclerosis .

    By its antioxidant property it protects cells from the damage by UV radiation, e.g. while tanning in a solarium. Used internally it helps against increased occurrence of bruises ; used topically it facilitates the regeneration of abrasions .

    Drags Imun diluted in water or combined with the preparation Vironal may be used as a gargle for sore throat . It reduces fever and combined with Cytovital eliminates pyretic conditions.

    Due to their cytostatic properties Drags Imun & Cytosan are suitable for use in oncology and in "herbal hiv treatment". Given their strong antiviral effects they also may be used as "herbal remedies for hiv" for the treatment of HIV patients, as well . Drags imun has been called a "natural cure for hiv and aids". In both cases we recommend the combination of larger doses (10 drops five times a day) of Drugs Imun with the preparation Cytosan (4 – 5 capsules three times a day) but only under physician's supervision.

    Drags imun, Grepofit, and Peralgin contain "herbs with natural antibiotic activity"

    Regeneration process and dosage:

    Use internally maxim 10 drops 1 – 3 times a day. Wash it down with water. After three weeks interrupt the treatment for one week. Increase your intake of fluids during the treatment, so as to stimulate the detoxification process.

    The preparation contains neither preservatives, nor additives.
    Shake well before use.
    Food supplement.
    Not suitable for children, pregnant and nursing women






    Re: Natural anti-retro viral therapies, very interesting plant !
    « Reply #1 on: September 20, 2010, 05:31:33 PM »
    QuoteModifyRemove
    Sangre de grado is a medium-sized to large tree that grows from 10–20 m high in the upper Amazon region of Peru, Ecuador, and Colombia. Although tall, the trunk is usually less than 30 cm in diameter and is covered by smooth, mottled bark. It has large, heart-shaped, bright-green leaves and unique, greenish-white flowers on long stalks. Its Peruvian name, sangre de grado, means “blood of the dragon” (in Spanish). In Ecuador, it’s named sangre de drago (which means “dragon’s blood” as well). When the trunk of the tree is cut or wounded, a dark red, sappy resin oozes out as if the tree is bleeding—earning this local name. The genus Croton is a large one, with 750 species of trees and shrubs distributed across the tropical and subtropical regions of both hemispheres. Crotons are rich in active alkaloids, and several species are well-known medicinal plants used as purgatives and tonics.

    Sangre de grado's red sap or latex (and also its bark) has a long history of indigenous use in the rainforest and in South America. The earliest written reference dates its use to the 1600s, when Spanish naturalist and explorer P. Bernabé Cobo found that the curative power of the sap was widely known throughout the indigenous tribes of Mexico, Peru, and Ecuador. For centuries, the sap has been painted on wounds to staunch bleeding, to accelerate healing, and to seal and protect injuries from infection. The sap dries quickly and forms a barrier, much like a "second skin." It is used externally by indigenous tribes and local people in Peru for wounds, fractures, and hemorrhoids, internally for intestinal and stomach ulcers, and as a douche for vaginal discharge. Other indigenous uses include treating intestinal fevers and inflamed or infected gums, in vaginal baths before and after childbirth, for hemorrhaging after childbirth, and for skin disorders.

    Sangre de grado resin and bark are used in traditional medicine in South America today in much the same manner as indigenous ones. In Peruvian herbal medicine it is recommended for hemorrhaging, as an antiseptic vaginal douche and, topically, for healing wounds. It is also used internally for ulcers in the mouth, throat, intestines and stomach; as an antiviral for upper respiratory viruses, stomach viruses and HIV; internally and externally for cancer and, topically, for skin disorders, insect bites and stings. In Brazilian traditional medicine the sap currently is used for wounds, hemorrhaging, diarrhea, mouth ulcers, and as a general tonic.

    Sangre de grado resin or sap contains phytochemicals including proanthocyanidins (antioxidants), simple phenols, diterpenes, phytosterols, and biologically active alkaloids and lignans Scientists have attributed many of the biologically active properties of the sap (especially its wound-healing capacity) to two main "active" constituents: an alkaloid named taspine, and a lignan named dimethylcedrusine.

    Of course, botanists, herbalists, and naturopaths would disagree with such reductionist conclusions (and often do); in this particular case, the matter is actually proven by science. Noted author and ex-USDA economic botanist Dr. James Duke summed this up eloquently, saying, "I like the comments on dragon's blood, and would add one further note: in addition to the proanthocyanadins (including Pycnogenol) and taspine, there's another active ingredient - dimethylcedrusine. While each of these alone - dimethylcedrusine, Pycnogenol and taspine - was shown to effectively heal wounded rats (with squares of skin exfoliated, i.e., peeled off) by European scientists, the whole dragon's blood was shown to speed healing four times faster. The whole was better than the sum of its parts. Synergy makes the whole herb stronger; diversity makes the rainforest stronger."

    The taspine alkaloid from sangre de grado was first documented with anti-inflammatory actions in 1979. In 1985 taspine was documented with anti-inflammatory, antitumorous (against sarcomas), and antiviral actions.

    The main plant chemicals in sangre de grado include: alpha-calacorene, alpha-copaene, alpha-pinene, alpha-thujene, beta-caryophyllene, beta-elemene, beta-pinene, betaine, bincatriol, borneol, calamenene, camphene, catechins, cedrucine, crolechinic acid, cuparophenol, D-limonene, daucosterol, dihydrobenzofuran, dimethylcedrusine, dipentene, eugenol, euparophenol, gallocatechin, gamma-terpinene, gamma-terpineol, hardwickiic acid, isoboldine, korberin A & B, lignin, linalool, magnoflorine, methylthymol, myrcene, norisoboldine, p-cymene, proanthocyanidins, procyanidins, resin, tannin, taspine, terpinen-4-ol, and vanillin.

    The Belgian scientists also determined that taspine was active against herpes virus in this study. In 1994 other phytochemicals were found, including phenolic compounds, proanthocyanadins, and diterpenes, which showed potent antibacterial activity (against E. coli and Bacillus subtilis) as well as wound-healing properties. Another study documented sangre de grado's antioxidant effects and researchers in Canada documented its antifungal properties. Another important traditional use of the sap was verified by clinical research in a 2000 study designed to evaluate its gastrointestinal effects. Researchers concluded that "Sangre de grado is a potent, cost-effective treatment for gastrointestinal ulcers and distress via antimicrobial, anti-inflammatory, and sensory afferent-dependent actions." In 2002, these same researchers reported that sangre de grado evidenced an in vitro effect against stomach cancer and colon cancer cells as well. In 2003 Italian researchers reported that the resin inhibited the growth of a human myelogenous leukemia cell line and also prevented cells from mutating in test tube studies.


    Extracts of sangre de grado have demonstrated antiviral activity against influenza, parainfluenza, herpes simplex viruses I and II, and hepatitis A and B. The antiviral and anti-diarrhea properties of sangre de grado have come to the attention of the pharmaceutical industry over the last 10 years. A U.S.-based pharmaceutical company has filed patents on three pharmaceutical preparations that contain antiviral constituents and novel chemicals (a group of plant flavonoids they've named SP-303), extracted from the bark and resin of sangre de grado. Their patented drugs include an oral product for the treatment of respiratory viral infections, a topical antiviral product for the treatment of herpes, and an oral product for the treatment of persistent diarrhea. These products have been the subject of various human clinical trials. Although the immunomodulating effects of sangre de grado have not been the subject of targeted research yet, some researchers believe that the anti-inflammatory, antimicrobial, and antioxidant activities may provide nonspecific immune enhancement effects as well.

    More recently, several scientific tests have been conducted on a proprietary sangre de grado product (made into a skin balm) which was also based on traditional uses. They reported that in pest control workers, a sangre de grado balm was preferred over placebo, for the relief of itching, pain, discomfort, swelling, and redness in response to wasps, fire ants, mosquitoes, bees, cuts, abrasions, and allergic plant reactions (poison ivy and others). Subjects reported relief within minutes, and that it provided pain relief and alleviated symptoms (itching and swelling) for up to six hours. These reported effects in humans as well as several other tests they conducted in animals and in vitro models of inflammation led them to conclude that sangre de grado prevents pain sensation by blocking the activation of nerve fibers that relay pain signals to the brain (therefore functioning as a broad-acting pain killer) as well as blocks the tissue response to a chemical released by nerves that promotes inflammation.

    [This Message was Edited on 09/24/2010]
  2. richvank

    richvank New Member

    Hi karinaxx.

    This is a new one to me, so I will have to study it. I'm a bit swamped right now, but will look into it when I can.

    Rich
  3. karinaxx

    karinaxx New Member

    Thank you for replying.
    I posted on various other boards, and it seems nobody is familiar with this plant and treatment. I actually found this information linked to AIDS treatments, used either alone , but mostly offered as an additional treatment to HAART treatment.
    Please do not forget to look into it; i am very interested to hear your opinion.

    It sounds very promising !

    Karinaxx
  4. Shannah

    Shannah Member

    aka Sangre de Grado
    aka Dragon's Blood

    Pubmed has 23 references to it. Here's a couple that may be helpful to those with technical knowledge of what it might mean for ME/CFS.

    2003 Sep;69(9):785-94.
    Immunomodulatory activity and chemical characterisation of sangre de drago (dragon's blood) from Croton lechleri.
    Risco E, Ghia F, Vila R, Iglesias J, Alvarez E, Cañigueral S.

    Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Universitat de Barcelona, Av. Diagonal 643, 08028 Barcelona, Spain.

    Abstract
    The immunomodulatory activity of the latex from Croton lechleri (sangre de drago) was determined by in vitro assays. Classical (CP) and alternative (AP) complement pathways activities were determined in human serum. Intracellular generation of reactive oxygen species (ROS) by human polymorphonuclear leukocytes (PMNs) and monocytes, and phagocytosis of opsonised fluorescent microspheres were measured by flow cytometry. Free radical scavenging activity was evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH). Activity on proliferation of murine lymphocytes was also investigated. In addition, anti-inflammatory activity was assayed in vivo by carrageenan-induced rat paw oedema test. Some of the activities were compared with those of the isolated alkaloid taspine. Sangre de drago from Croton lechleri showed immunomodulatory activity. It exhibited a potent inhibitory activity on CP and AP of complement system and inhibited the proliferation of activated T-cells. The latex showed free radical scavenging capacity. Depending on the concentration, it showed antioxidant or prooxidant properties, and stimulated or inhibited the phagocytosis. Moreover, the latex has strong anti-inflammatory activity when administered i. p. Taspine cannot be considered the main responsible for these activities, and other constituents, probably proanthocyanidins, should be also involved.

    PMID: 14598201 [PubMed - indexed for MEDLINE]

    also

    2009 Aug;16(8):768-75. Epub 2009 Apr 29.
    Activity of sap from Croton lechleri on rat vascular and gastric smooth muscles.
    Froldi G, Zagotto G, Filippini R, Montopoli M, Dorigo P, Caparrotta L.

    Department of Pharmacology and Anaesthesiology, University of Padova, Padua, Italy. g.froldi@unipd.it

    Abstract
    The effects of red sap from Croton lechleri (SdD), Euphorbiaceae, on vascular and gastric smooth muscles were investigated. SdD, from 10 to 1000 microg/ml, induced concentration-dependent vasoconstriction in rat caudal arteries, which was endothelium-independent. In arterial preparations pre-constricted by phenylephrine (0.1 microM) or KCl (30 mM), SdD also produced concentration-dependent vasoconstriction. To study the mechanisms implicated in this effect we used selective inhibitors such as prazosin (0.1 microM), an antagonist of alpha(1)-adrenoceptors, atropine (0.1 microM), an antagonist of muscarinic receptors, and ritanserin (50 nM), a 5-HT(2A) antagonist; none of these influenced vasoconstriction caused by SdD. Likewise, nifedipine (50 nM), an inhibitor of L-type calcium channels, did not modify the action of SdD. Capsaicin (100 nM), an agonist of vanilloid receptors, also did not affect vasoconstriction by SdD. We also investigated the action of SdD (10-1000 microg/ml) on rat gastric fundus; per se the sap slightly increased contractile tension. When the gastric fundus was pre-treated with SdD (100 microg/ml) the contraction induced by carbachol (1 microM) was increased, whereas that by KCl (60mM) or capsaicin (100 nM) were unchanged. The data shows that SdD increased contractile tension in a concentration-dependent way, both on vascular and gastric smooth muscles. The vasoconstriction is unrelated to alpha(1), M, 5-HT(2A) and vanilloid receptors as well as L-type calcium channels. SdD increased also contraction by carbachol on rat gastric fundus. Thus for the first time, experimental data provides evidence that sap from C. lechleri owns constricting activity on smooth muscles.

    PMID: 19406630 [PubMed - indexed for MEDLINE]

    also

    2001 Dec;6(6):567-79.
    Review of antiviral and immunomodulating properties of plants of the Peruvian rainforest with a particular emphasis on Una de Gato and Sangre de Grado.
    Williams JE.

    California Acupuncture College, San Diego, CA, USA. drwilliams665@home.com

    Abstract
    Viral diseases, including emerging and chronic viruses, are an increasing worldwide health concern. As a consequence, the discovery of new antiviral agents from plants has assumed more urgency than in the past. A number of native Amazonian medicines of plant origin are known to have antimicrobial and anti-inflammatory activity, although only a few have been studied for their antiviral properties and immunomodulating effects. Those most studied include: Sangre de Grado (drago) (Croton lechleri) in the Euphorbiaceae family and Una de Gato (Uncaria tomentosa) in the Rubiaceae family. This article reviews the chemical composition, pharmacological properties, state of current research, clinical use, and potential antiviral and immunomodulating activity of these and other plants from the Peruvian Amazon.

    PMID: 11804547 [PubMed - indexed for MEDLINE]

  5. karinaxx

    karinaxx New Member

    I will forward this to some science wizards. Hopefully i can bring some more detailed info back h in relation to treating ME/CFS with this.

    Karinaxx
  6. Shannah

    Shannah Member

    Karinaxx,

    Any feedback on this yet by any chance?