I don't want to hijak that thread so I am starting a new one. I have had problems with some of the supplements for the methylation block and so thus far have not tried your actual protocol for that reason. I still very much want to try it and I am positive that the reason I have the issues is because my gut is seriously messed up. I am very slowly getting to doctors to try to work on that but have been so sick (& have such an insane sleep/wake cycle), it is taking a really long time. So, what I am wondering is about the possibility of supplementing with glutathione until I am able to get the stomach stuff at least somewhat improved. (I know that you don't normally advise simply supplementing with glutathione and I pretty much understand why .....it's not a long term solution). Anyway, I have two questions about this based on what you wrote to scapper re the digestive system. One: Is the point you made re toxins being mobilized an issue that arises from the methylation block treatment itself, or is it due to the resulting production of glutathione that occurs once that block is removed? I mean, if it's due to the glutahione itself, then obviously it wouldn't make sense to try that as a short term thing because it would likely make me sicker and it's an expensive treatment to try. However, at this point if taking glutahione itself would help even a little until I could try the protocol, it would be worth it, and might help me get to Drs sooner and get other stuff a little more under control so that I can try the protocol sooner, too. And two: Would it even be likely that my body would be able to utilize any of the glutahione if my stomach is so screwed up? And actually, I have a third question, too: Do you know what sort of treatments the Dr you mentioned is using for the stomach stuff? I realize that there are a variety of gut issues, so you may not really be able to answer this one, but I am curious becasue so far everything that Drs have tried with me for those issues (both to figure out exactly what is going on, and to try to treat it) has only made things worse. Probiotics (tried several different ones, too) especially worsened things and those seem to be one of the standard digestive treatments. At this point, there are almost no foods that I can eat and actually digest them properly (or at all - a lot of them come rt back up). And, yet, digestive enzymes have also not been helpful. Anyway, thanks for any input you can give.