For Rich & any other interested readers: I've been concerned about the low level of choline in my diet due to various food intolerances & sensitivities. My average intake is about 900 mg/week (incl. 50 mg/day in multivite), while the RDA for women is around 450 mg/day. While I would not call myself a depressed person under normal circumstances, when I've tried to increase my choline intake w/supps (phosphatidyl choline, choline bitartrate, lecithin), I've found that a single dose leaves me in a fairly severe depressive state that takes the better part of a week to resolve. FWIW, I have a family hx of major depression, mother does best on anticholinergic ADs, son hasn't done well on any AD tried, but we have discovered he is also extremely choline sensitive -- a small dose of DMAE for example renders him practically catatonic, complete w/waxy posturing. The biochem charts I've peeked at suggest that choline somehow feeds into or its metabolism is fed by the methylation cycle. Pfeiffer Treatment Center (son was eval'd there) maintains that undermethylators are choline-sensitive; however son's eval results there were not a slamdunk for undermethylation. I've tried taking choline with a little 5-MTHF (200 mcg. folinic acid), but no improvement in tolerance. Any comments or suggestions? Thanks.