Hi Rich- I posted on frango's thread but thought I would post here so as not to hijack it. I'm trying to figure out some puzzling information. My MSH is low, MMP9 high, C4a levels normal. I have the multi susceptible genotype. There are probable mold issues where I live. Does the normal C4a level mean my immune system is processing the mold? Or something else. It seems that it should be high. It won't make a difference in my treatment but it just doesn't make sense to me that the C4a is normal. Can viruses cause an increase in MMP9 and lower the MSH. I can't find where Dr. Shoemaker addresses viral infections. Maybe he doesn't. I'm also wondering if it's possible to assume that those with the multi susceptible genotype automatically have problems with the methylation cycle? I think my doctor is wanting to go in the viral treatment direction based on the normal C4a values. I'm really looking forward to reading your paper that pulls all these theories together. It's hard to do when brain fogged. Thanks for everything.