Wondering if you can figure this out for me. In the past, I have taken Methylcobalamin injections with no problem. For the past year, have been using Hydroxocobalamin 2500 mcg. with no problem. I never experienced an increase in energy, but they did help clear my head. Yesterday, I took a new script by a new doctor, for Methylcobalamin 1000 mcg. which was (apparently) diluted in a Buffered Saline. Within an hour, I started itching and burning eyes, to the point I had to squint. Itching in all mucous membranes and externally as well. It's been 20 hours since I took the injection and still itching like mad. I called the compounding pharmacist and she gave me the above stats and that it was a yeast free methylcobalamin, as requested. She couldn't guess why this is happening. I'm wondering if you know how it might be related to Methylation problems. I also have MTHFR deficiency. I also took a second dose of Diflucan yesterday as I have had 6 courses of various antibiotics since the end of July as I have a UTI of Group B Strept that I cannot get rid of. Thanks for any help.