Hi there- I am still doing methylation, although I don't seem to be seeing any added benefits since the initial positive effects. It has been about a year now. I recently started progesterone and have found that it seems to have helped with some of the inflammation that I have going on. My C4a is down now from about 20,000 to 1800. My pain is also down about 50%. I believe that the progesterone has something to do with this since it counteracts estrogen which causes inflammation. My questions are... Does a methylation defect seem to affect hormonal imbalances? I have symptoms of Hypothyroid, but a normal thyroid panel. My body makes ONLY estrogen. I think that my initial Lyme infection has something to do with this since Lyme seems to deplete B vitamins which are necessary for hormone function. There are others with these same issues so I am wondering what your thoughts are on any correlation. Also, I know you were starting to look into Lyme as a precursor for the methylation defect. Do you have any updates on your thoughts there? Is is possible that successfully treating Lyme, which supposedly thrives off of B vitamins in the body, would unlock the methylation defect? Thanks in advance!