Role of chronic infection in FM +CFS (even a stubborn cough)

Discussion in 'Fibromyalgia Main Forum' started by Rozmund, Nov 19, 2002.

  1. Rozmund

    Rozmund New Member


    Chronic Infections in Fibromyalgia Syndrome: Sources of Morbidity and Illness Progression
    ImmuneSupport.com

    09-30-2002

    By Prof. Garth L. Nicolson

    The Institute for Molecular Medicine

    15162 Triton Lane, Huntington Beach, CA 92649-1401

    (From "The Fibromyalgia Survivor 2000")

    Fibromyalgia Syndrome (FMS) is characterized by muscle pain and tenderness at specific
    sites, but there are also a number of other less specific chronic signs and symptoms.
    Among these are disabling fatigue, impairments in short-term memory, headaches,
    gastrointestinal and vision problems and sometimes intermittent low-grade fevers, joint
    pain and other signs and symptoms.

    In many patients, the diagnosis of FMS is accompanied by other secondary diagnoses,
    such as Chronic Fatigue Syndrome (CFS), Rheumatoid Arthritis (RA), Inflammatory Bowel
    Diseases, and other syndromes, which can also present with overlapping signs and
    symptoms. This suggests that although the exact causes of these illnesses are not known
    and may be different in each patient, there are similarities in these conditions that may be
    important in patient morbidity (sickness) or in illness progression [1].

    Instead of concentrating on possible causes of FMS, we have been interested in the
    progression of chronic illnesses like FMS and in the potential role that chronic infections
    may play in FMS. The complex signs and symptoms that evolve in many FMS, CFS and RA
    patients may be due, in part, to systemic chronic infections (bacteria, viruses, fungi). Such
    infections can follow acute or chronic chemical, environmental or other insults (trauma,
    chemical exposures, acute viral illness, etc.) that have the potential to suppress the
    immune system and cause metabolic imbalances [1].

    Illness Progression in FMS Patients

    Illnesses like FMS evolve over time, probably in a multistep process that may require
    multiple toxic exposures, including infections that could be causative for the illness in a few
    patients, cofactors for the illness (not causative but important in patient morbidity) in
    others, or more likely in most patients, opportunistic infections that cause morbidity. Such
    infections need not be present at the onset of illness to be important. Because of their
    dysfunctional metabolic and immune systems, many FMS patients may be particularly
    susceptible to chronic infections that worsen their illness. Of course, illness progression in
    FMS patients could also be caused by other factors, psychological stress, physical trauma,
    other illnesses and many other factors [2].

    Chronic infections are usually held in check by our immune systems, but they can take hold
    if they can avoid immune surveillance and penetrate and hide in various tissues and
    organs, including muscle cells and nerve cells. When such "stealth" viral and bacterial
    infections occur, they can cause many of the complex signs and symptoms seen in FMS,
    CFS, RA and GWI, including enhanced immune dysfunction and metabolic imbalances [1, 2].
    Changes in environmental responses as well as increased titers to various endogenous
    viruses that are commonly found to be expressed in these patients have been seen in
    FMS, CFS and GWI patients. If infectious agents are involved, few can produce the complex
    chronic signs and symptoms found in these patients. One that can is represented by a
    small, primitive class of bacteria called mycoplasmas [3]. Mycoplasmas and other bacteria
    (Chlamydia, Coxiella, Brucella, Borelia, etc.), although not as well known as other agents in
    causing various diseases, are now considered important emerging pathogens in various
    chronic illnesses.

    As chronic illnesses such as FMS, CFS and RA progress, there are a number of
    accompanying clinical problems, and in some patients show increases in autoimmune signs
    and symptoms. This suggests that they do not have classical autoimmune diseases but
    they may have incomplete diagnoses for these diseases. Although it is certainly not
    proven, this pattern is consistent with certain chronic infections, such as mycoplasmal
    infections, that penetrate into nerve cells, synovial cells in joints, muscle cells and other cell
    types. Microorganisms like mycoplasmas can incorporate into their own surface structures
    pieces of host cell membranes that contain important host membrane antigens that can
    trigger autoimmune responses [1], and they can also mimic host cell antigen structures [3].
    Thus patients with such infections may respond immunologically to microorganism antigens
    as well as their own membrane antigens, producing unusual autoimmune signs and
    symptoms. This could explain why such patients do not have all of the clinical
    characteristics expected in these usually rare autoimmune diseases.

    Microorganisms Can Cause Morbidity in FMS Patients

    Microorganisms like Mycoplasmas are not considered important human pathogens when
    they are found at superficial sites, such as the oral cavity or gut, but some species, such as
    M. fermentans, M. penetrans, M. pneumoniae, M. genitalium, M. pirum and M. hominis,
    among others, have the capacity to penetrate into the blood circulation and colonize
    various tissues, and these cell-penetrating microorganisms have been closely associated
    with various human diseases [1, 3]. Do such infectious agents actually cause FMS, CFS or
    RA? Probably not on their own, but some bacteria and viruses appear to be an important
    element in causing chronic illness progression, patient morbidity, or exacerbating the major
    signs and symptoms seen in patients with chronic illnesses.

    We have found that ~70% of FMS, ~60% of CFS and ~50% of RA and Gulf War Illness
    patients have mycoplasmal blood infections that can explain many of the chronic signs and
    symptoms found in these patients. In the majority of FMS and CFS patients we have found
    multiple pathogenic mycoplasmas in their white blood cells but these infections are only
    found in 0-9% of controls [1, 4]. Interestingly, the majority of CFS and FMS patients had
    multiple mycoplasmal infections but none were found in controls [4]; however, single
    infections are found in some nonsymptomatic subjects (0-9%). The tests that we use to
    identify mycoplasmal infections, Forensic Polymerase Chain Reaction, are very sensitive
    and highly specific. These tests are a dramatic improvement over the relatively insensitive
    serum antibody and other tests that have been used to assay for systemic infections.

    New Treatments for FMS and other Chronic Illnesses

    When microorganism infections are identified in the blood of patients, they should be
    treated as medical not psychiatric patients, just like any other patients with blood
    infections. This does not mean that psychological or psychiatric problems are not important
    in chronic illness patients. But if such infections are important in these disorders, then
    appropriate treatments with antibiotics or other medications that suppress chronic
    infections should result in improvement and even recovery. This is exactly what has been
    found [1, 2]. The majority of patients with confirmed pathogenic mycoplasmal infections
    eventually recover from 50-100% of their premorbid health on therapies that are directed
    specifically against their chronic infections not against possible psychological problems [2].

    The recommended treatment for confirmed mycoplasmal blood infections is long-term
    antibiotic therapy, usually multiple 6-week cycles of doxycycline (200-300 mg/day),
    ciprofloxacin or Cipro (1,500 mg/day), azithromycin or Zithromax (500 mg/day) or
    clarithromycin or Biaxin (750-1,000 mg/day). Multiple cycles are required, because few
    patients recover after only a few cycles, possibly because of the intracellular locations of
    the infections, the slow-growing nature of these microorganisms and their inherent
    insensitivity to antibiotics. We now recommend that patients who have been diagnosed
    with blood infections receive continuous oral antibiotics for at least 6 months before using
    the 6-week cycles of treatment. Although patients starting such therapy usually have
    Herxheimer reactions and feel initially worse due to die-off or release of toxic materials
    from damaged microorganisms, they eventually stabilize within days to a few weeks and
    then slowly begin to recover. Unfortunately, the treatment requires long-term therapy, and
    recovery is usually very slow. Patients that have been sick for many years are unlikely to
    recover within a year of therapy [5].

    The clinical responses that are seen are not due to placebo effects, because administration
    of some antibiotics, such as penicillins, resulted in patients becoming more not less
    symptomatic. In addition, they are not due to immunosuppressive effects of some of the
    antibiotics, because other antibiotics that do not cause immune suppression are also
    effective but only if they suppress the chronic infections. If they don’t have these
    infections, then antibiotics should not work [2]. Some patients recover to a certain point
    and then fail to continue to respond to the recommended antibiotics, suggesting that other
    problems, such as viral infections, environmental exposures and other toxic events, and
    even stress, also play an important role in these illnesses, and may even play a
    predominant role in some patients.

    What results have been obtained with antibiotics for chronic illnesses like FMS? Although a
    majority of patients diagnosed with chronic blood infections appear to benefit from
    antibiotic therapy, many patients respond and have some alleviation of most signs and
    symptoms but do not fully recover. A 3-year follow-up of antibiotic therapy in Northern
    California indicates that a majority (~80%) of FMS/CFS) patients from Shasta County that
    were confirmed with mycoplasmal infections recovered from 50-100% of their pre-illness
    health within this time period, and even some patients who did not test positive showed
    benefit from antibiotics, suggesting other bacterial infections. Similar to other therapies for
    chronic illnesses, not every patient benefited from antibiotic therapy, and the time required
    for recovery was quite variable in different patients [3]. In some patients oxygen therapy
    has proved useful. Oxygen suppresses the anaerobic chronic infections like mycoplasmas.

    In addition to antibiotics, patients must take vitamins, minerals, immune enhancement and
    other supplements to help boost immunity. . For example, these patients are often
    depleted in vitamins B complex, C and E, among others, and certain minerals [5]. Amino
    acids, fish oils, probiotic bacteria (Lactobacillus acidophillus) and a number of natural
    remedies have proven useful during therapy [5].

    Complex Causes of Chronic Illnesses

    Do chronic infections explain illnesses like FMS? It is unlikely that there is only one or even
    a few explanations for complex chronic illnesses like FMS or CFS. Rather, these illnesses
    are probably due to a combination of multiple toxic exposures, chemical and biological, in
    combination with genetic susceptibility (immune systems and/or detoxification systems,
    cellular metabolism) that determines whether a person becomes chronically ill. These
    considerations probably also play an important role in determining who will recover to
    various extents on different types of therapy. In addition, recovery can be complicated by
    patients’ over-dependence on drugs, such as certain antidepressants or other drugs that
    can suppress portions of the immune system. Interestingly, those patients that slowly
    recover after several cycles of antibiotics are generally less environmentally sensitive,
    suggesting that their immune systems may be returning to pre-illness states. If such
    patients had illnesses that were solely caused by psychological or psychiatric problems or
    by environmental or chemical exposures, they should not respond to the recommended
    antibiotics and recover their health. In addition, if such treatments were just reducing the
    autoimmune responses, then patients should not maintain recovery after the treatments
    are discontinued.

    For Further Information

    The Institute for Molecular Medicine can test patients for evidence of mycoplasmal and
    other infections (Chlamydia, Borrelia, HHV-6, CMV) of the types that worsen human
    diseases like FMS, CFS, RA and Gulf War Illness. Blood samples can be sent to the Institute
    for Molecular Medicine’s new certified reference laboratory, International Molecular
    Diagnostics, Inc. for mycoplasma and other testing (Tel: 714-799-7177). The Institute’s
    website for further information is: www.immed.org. International Molecular Diagnostics,
    Inc. website is www.imd-lab.com.

    Contact:

    Prof. Garth L. Nicolson

    The Institute for Molecular Medicine

    15162 Triton Lane

    Huntington Beach, CA 92649-1401

    Tel: 714-903-2900 Fax: 714-379-2082; email: gnicolson@immed.org

    References

    1. Nicolson, G.L., Nasralla, M, Hier, J., Erwin, R., Nicolson, N.L. and Ngwenya, R. Mycoplasmal
    infections in chronic illnesses: Fibromyalgia and Chronic Fatigue Syndromes, Gulf War
    Illness, HIV-AIDS and Rheumatoid Arthritis. Med. Sentinel 1999; 4:172-176.

    2. Nicolson, G.L. The role of microorganism infections in chronic illnesses: support for
    antibiotic regimens. CFIDS Chronicle 1999; 12(3):19-21.

    3. Baseman, J.B. and Tully, J.G. Mycoplasmas: Sophisticated, reemerging, and burdened by
    their notoriety. Emerg. Infect. Dis. 1997; 3:21-32.

    4. Nasralla, M., Haier, J. and Nicolson, G.L. Multiple mycoplasmal infections detected in
    blood of Chronic Fatigue and Fibromyalgia Syndrome patients. Eur. J. Clin. Microbiol. Infect.
    Dis. 1999; in press.

    5. Nicolson, G.L. Considerations when undergoing treatment for chronic infections found in
    Chronic Fatigue Syndrome, Fibromyalgia Syndrome and Gulf War Illnesses. (Part 1).
    Antibiotics Recommended when indicated for treatment of Gulf War Illness/CFIDS/FMS (Part
    2). Intern. J. Med. 1998; 1:115-117, 123-128.



  2. Rozmund

    Rozmund New Member


    Chronic Infections in Fibromyalgia Syndrome: Sources of Morbidity and Illness Progression
    ImmuneSupport.com

    09-30-2002

    By Prof. Garth L. Nicolson

    The Institute for Molecular Medicine

    15162 Triton Lane, Huntington Beach, CA 92649-1401

    (From "The Fibromyalgia Survivor 2000")

    Fibromyalgia Syndrome (FMS) is characterized by muscle pain and tenderness at specific
    sites, but there are also a number of other less specific chronic signs and symptoms.
    Among these are disabling fatigue, impairments in short-term memory, headaches,
    gastrointestinal and vision problems and sometimes intermittent low-grade fevers, joint
    pain and other signs and symptoms.

    In many patients, the diagnosis of FMS is accompanied by other secondary diagnoses,
    such as Chronic Fatigue Syndrome (CFS), Rheumatoid Arthritis (RA), Inflammatory Bowel
    Diseases, and other syndromes, which can also present with overlapping signs and
    symptoms. This suggests that although the exact causes of these illnesses are not known
    and may be different in each patient, there are similarities in these conditions that may be
    important in patient morbidity (sickness) or in illness progression [1].

    Instead of concentrating on possible causes of FMS, we have been interested in the
    progression of chronic illnesses like FMS and in the potential role that chronic infections
    may play in FMS. The complex signs and symptoms that evolve in many FMS, CFS and RA
    patients may be due, in part, to systemic chronic infections (bacteria, viruses, fungi). Such
    infections can follow acute or chronic chemical, environmental or other insults (trauma,
    chemical exposures, acute viral illness, etc.) that have the potential to suppress the
    immune system and cause metabolic imbalances [1].

    Illness Progression in FMS Patients

    Illnesses like FMS evolve over time, probably in a multistep process that may require
    multiple toxic exposures, including infections that could be causative for the illness in a few
    patients, cofactors for the illness (not causative but important in patient morbidity) in
    others, or more likely in most patients, opportunistic infections that cause morbidity. Such
    infections need not be present at the onset of illness to be important. Because of their
    dysfunctional metabolic and immune systems, many FMS patients may be particularly
    susceptible to chronic infections that worsen their illness. Of course, illness progression in
    FMS patients could also be caused by other factors, psychological stress, physical trauma,
    other illnesses and many other factors [2].

    Chronic infections are usually held in check by our immune systems, but they can take hold
    if they can avoid immune surveillance and penetrate and hide in various tissues and
    organs, including muscle cells and nerve cells. When such "stealth" viral and bacterial
    infections occur, they can cause many of the complex signs and symptoms seen in FMS,
    CFS, RA and GWI, including enhanced immune dysfunction and metabolic imbalances [1, 2].
    Changes in environmental responses as well as increased titers to various endogenous
    viruses that are commonly found to be expressed in these patients have been seen in
    FMS, CFS and GWI patients. If infectious agents are involved, few can produce the complex
    chronic signs and symptoms found in these patients. One that can is represented by a
    small, primitive class of bacteria called mycoplasmas [3]. Mycoplasmas and other bacteria
    (Chlamydia, Coxiella, Brucella, Borelia, etc.), although not as well known as other agents in
    causing various diseases, are now considered important emerging pathogens in various
    chronic illnesses.

    As chronic illnesses such as FMS, CFS and RA progress, there are a number of
    accompanying clinical problems, and in some patients show increases in autoimmune signs
    and symptoms. This suggests that they do not have classical autoimmune diseases but
    they may have incomplete diagnoses for these diseases. Although it is certainly not
    proven, this pattern is consistent with certain chronic infections, such as mycoplasmal
    infections, that penetrate into nerve cells, synovial cells in joints, muscle cells and other cell
    types. Microorganisms like mycoplasmas can incorporate into their own surface structures
    pieces of host cell membranes that contain important host membrane antigens that can
    trigger autoimmune responses [1], and they can also mimic host cell antigen structures [3].
    Thus patients with such infections may respond immunologically to microorganism antigens
    as well as their own membrane antigens, producing unusual autoimmune signs and
    symptoms. This could explain why such patients do not have all of the clinical
    characteristics expected in these usually rare autoimmune diseases.

    Microorganisms Can Cause Morbidity in FMS Patients

    Microorganisms like Mycoplasmas are not considered important human pathogens when
    they are found at superficial sites, such as the oral cavity or gut, but some species, such as
    M. fermentans, M. penetrans, M. pneumoniae, M. genitalium, M. pirum and M. hominis,
    among others, have the capacity to penetrate into the blood circulation and colonize
    various tissues, and these cell-penetrating microorganisms have been closely associated
    with various human diseases [1, 3]. Do such infectious agents actually cause FMS, CFS or
    RA? Probably not on their own, but some bacteria and viruses appear to be an important
    element in causing chronic illness progression, patient morbidity, or exacerbating the major
    signs and symptoms seen in patients with chronic illnesses.

    We have found that ~70% of FMS, ~60% of CFS and ~50% of RA and Gulf War Illness
    patients have mycoplasmal blood infections that can explain many of the chronic signs and
    symptoms found in these patients. In the majority of FMS and CFS patients we have found
    multiple pathogenic mycoplasmas in their white blood cells but these infections are only
    found in 0-9% of controls [1, 4]. Interestingly, the majority of CFS and FMS patients had
    multiple mycoplasmal infections but none were found in controls [4]; however, single
    infections are found in some nonsymptomatic subjects (0-9%). The tests that we use to
    identify mycoplasmal infections, Forensic Polymerase Chain Reaction, are very sensitive
    and highly specific. These tests are a dramatic improvement over the relatively insensitive
    serum antibody and other tests that have been used to assay for systemic infections.

    New Treatments for FMS and other Chronic Illnesses

    When microorganism infections are identified in the blood of patients, they should be
    treated as medical not psychiatric patients, just like any other patients with blood
    infections. This does not mean that psychological or psychiatric problems are not important
    in chronic illness patients. But if such infections are important in these disorders, then
    appropriate treatments with antibiotics or other medications that suppress chronic
    infections should result in improvement and even recovery. This is exactly what has been
    found [1, 2]. The majority of patients with confirmed pathogenic mycoplasmal infections
    eventually recover from 50-100% of their premorbid health on therapies that are directed
    specifically against their chronic infections not against possible psychological problems [2].

    The recommended treatment for confirmed mycoplasmal blood infections is long-term
    antibiotic therapy, usually multiple 6-week cycles of doxycycline (200-300 mg/day),
    ciprofloxacin or Cipro (1,500 mg/day), azithromycin or Zithromax (500 mg/day) or
    clarithromycin or Biaxin (750-1,000 mg/day). Multiple cycles are required, because few
    patients recover after only a few cycles, possibly because of the intracellular locations of
    the infections, the slow-growing nature of these microorganisms and their inherent
    insensitivity to antibiotics. We now recommend that patients who have been diagnosed
    with blood infections receive continuous oral antibiotics for at least 6 months before using
    the 6-week cycles of treatment. Although patients starting such therapy usually have
    Herxheimer reactions and feel initially worse due to die-off or release of toxic materials
    from damaged microorganisms, they eventually stabilize within days to a few weeks and
    then slowly begin to recover. Unfortunately, the treatment requires long-term therapy, and
    recovery is usually very slow. Patients that have been sick for many years are unlikely to
    recover within a year of therapy [5].

    The clinical responses that are seen are not due to placebo effects, because administration
    of some antibiotics, such as penicillins, resulted in patients becoming more not less
    symptomatic. In addition, they are not due to immunosuppressive effects of some of the
    antibiotics, because other antibiotics that do not cause immune suppression are also
    effective but only if they suppress the chronic infections. If they don’t have these
    infections, then antibiotics should not work [2]. Some patients recover to a certain point
    and then fail to continue to respond to the recommended antibiotics, suggesting that other
    problems, such as viral infections, environmental exposures and other toxic events, and
    even stress, also play an important role in these illnesses, and may even play a
    predominant role in some patients.

    What results have been obtained with antibiotics for chronic illnesses like FMS? Although a
    majority of patients diagnosed with chronic blood infections appear to benefit from
    antibiotic therapy, many patients respond and have some alleviation of most signs and
    symptoms but do not fully recover. A 3-year follow-up of antibiotic therapy in Northern
    California indicates that a majority (~80%) of FMS/CFS) patients from Shasta County that
    were confirmed with mycoplasmal infections recovered from 50-100% of their pre-illness
    health within this time period, and even some patients who did not test positive showed
    benefit from antibiotics, suggesting other bacterial infections. Similar to other therapies for
    chronic illnesses, not every patient benefited from antibiotic therapy, and the time required
    for recovery was quite variable in different patients [3]. In some patients oxygen therapy
    has proved useful. Oxygen suppresses the anaerobic chronic infections like mycoplasmas.

    In addition to antibiotics, patients must take vitamins, minerals, immune enhancement and
    other supplements to help boost immunity. . For example, these patients are often
    depleted in vitamins B complex, C and E, among others, and certain minerals [5]. Amino
    acids, fish oils, probiotic bacteria (Lactobacillus acidophillus) and a number of natural
    remedies have proven useful during therapy [5].

    Complex Causes of Chronic Illnesses

    Do chronic infections explain illnesses like FMS? It is unlikely that there is only one or even
    a few explanations for complex chronic illnesses like FMS or CFS. Rather, these illnesses
    are probably due to a combination of multiple toxic exposures, chemical and biological, in
    combination with genetic susceptibility (immune systems and/or detoxification systems,
    cellular metabolism) that determines whether a person becomes chronically ill. These
    considerations probably also play an important role in determining who will recover to
    various extents on different types of therapy. In addition, recovery can be complicated by
    patients’ over-dependence on drugs, such as certain antidepressants or other drugs that
    can suppress portions of the immune system. Interestingly, those patients that slowly
    recover after several cycles of antibiotics are generally less environmentally sensitive,
    suggesting that their immune systems may be returning to pre-illness states. If such
    patients had illnesses that were solely caused by psychological or psychiatric problems or
    by environmental or chemical exposures, they should not respond to the recommended
    antibiotics and recover their health. In addition, if such treatments were just reducing the
    autoimmune responses, then patients should not maintain recovery after the treatments
    are discontinued.

    For Further Information

    The Institute for Molecular Medicine can test patients for evidence of mycoplasmal and
    other infections (Chlamydia, Borrelia, HHV-6, CMV) of the types that worsen human
    diseases like FMS, CFS, RA and Gulf War Illness. Blood samples can be sent to the Institute
    for Molecular Medicine’s new certified reference laboratory, International Molecular
    Diagnostics, Inc. for mycoplasma and other testing (Tel: 714-799-7177). The Institute’s
    website for further information is: www.immed.org. International Molecular Diagnostics,
    Inc. website is www.imd-lab.com.

    Contact:

    Prof. Garth L. Nicolson

    The Institute for Molecular Medicine

    15162 Triton Lane

    Huntington Beach, CA 92649-1401

    Tel: 714-903-2900 Fax: 714-379-2082; email: gnicolson@immed.org

    References

    1. Nicolson, G.L., Nasralla, M, Hier, J., Erwin, R., Nicolson, N.L. and Ngwenya, R. Mycoplasmal
    infections in chronic illnesses: Fibromyalgia and Chronic Fatigue Syndromes, Gulf War
    Illness, HIV-AIDS and Rheumatoid Arthritis. Med. Sentinel 1999; 4:172-176.

    2. Nicolson, G.L. The role of microorganism infections in chronic illnesses: support for
    antibiotic regimens. CFIDS Chronicle 1999; 12(3):19-21.

    3. Baseman, J.B. and Tully, J.G. Mycoplasmas: Sophisticated, reemerging, and burdened by
    their notoriety. Emerg. Infect. Dis. 1997; 3:21-32.

    4. Nasralla, M., Haier, J. and Nicolson, G.L. Multiple mycoplasmal infections detected in
    blood of Chronic Fatigue and Fibromyalgia Syndrome patients. Eur. J. Clin. Microbiol. Infect.
    Dis. 1999; in press.

    5. Nicolson, G.L. Considerations when undergoing treatment for chronic infections found in
    Chronic Fatigue Syndrome, Fibromyalgia Syndrome and Gulf War Illnesses. (Part 1).
    Antibiotics Recommended when indicated for treatment of Gulf War Illness/CFIDS/FMS (Part
    2). Intern. J. Med. 1998; 1:115-117, 123-128.



  3. Mikie

    Mikie Moderator

    Dr. Nicolson is to mycoplasmas what Dr. Cheney is to CFIDS, and Dr. St. Amand is to the Guai treatment.

    One thing that is either not mentioned in this article, or I missed it, is that Dr. Nicolson recommends using colloidal silver along with the antibiotics. I have been using probiotics for years and have not had the antibiotics upset my stomach. I use colostrum and whey to try to rebuild my immune system.

    While on antibiotics, my chronic sore throats, swollen lymph nodes, low-grad temperatures, migraine-type headaches, and IBS go away. Three days off the antibiotics, and they reappear. Since I've been sick for 12 years, I expect it will take a while for the antibiotics to get rid of the mycoplasmas.

    Love, Mikie