on a whim I decided to try SAM-e again the other day, there was a sale or something. I broke about 1/10 of a tab and took it and felt sedated later than now for 2 days after feel like crap, herxy and slight headache, think its related. I forgot how it used to affect me years ago but I seem to just more sensitive w/age. Anyone know if its known to cause possible herx or detox? Isn't it related into methylation? N-acetyl cysteine hosed me w/awful headaches a couple years ago when tried it. I will look up the meth protocol for glut again.