I've been on this for almost two weeks. I am titrating up slower than the directions because of the severe nausea I'm having. The doc gave me Zofran for the nausea which I have to take 3-4 times a day. I do find though that I am having some relief from the chronic fibro pain. I had tried Lyrica for nine months w/o relief but did gain a lot of weight. Weight gain is not a side effect of this though but hyperthyroid is. I stopped taking my thyroid medicine. It doesn't work anyways but I didn't want to go hyper-hyperthyroid. We'll see what happens & I'll have to keep you updated.