Scared to try Provigil

Discussion in 'Fibromyalgia Main Forum' started by annade, May 28, 2008.

  1. annade

    annade New Member

    I just saw my rheumy today and he feels that I should try Provigil to address my energy and cognitive difficulties. I am very sensitive to meds. and although I know several people on this site have had success with it, I have also read posts from those who have had very adverse reactions. I know we are all different and respond differently to various meds., so nobody can really give me advice on this.

    I am also concerned about trying it because it clearly states on the info. brochure that if you have a systemic fungal infection (eg. candidas) that you should not take this med. I have been tested for candidas (bloodtest) and know that candidas is an issue for me. My rheumy knows my history and I again reminded him of my issues with candida. He felt I should still do okay on this med.

    Has anyone here tried Provigil who also had issues with candida? Just curious. My gut says to not try it, but am interested to see what others think. Thanks for your input.

  2. erica741

    erica741 New Member

    Hi Deanna, I have been taking Provigil for about 2 months and it really has been a godsend for me. I am still pretty much housebound, but Provigil enables me to stay alert enough to spend hours on the internet, watch dvds, and other stuff I would otherwise be too exhausted to enjoy.

    Besides getting really bad headaches for the 1st few days (common early side effect), I have tolerated Provigil well.

    I did notice that I got bloated and slightly constipated since starting it. I wonder if those symptoms are related to candida?

    Maybe you should try it for a bit and see what happense? Keep me posted if you decide to try it.

  3. annade

    annade New Member

    bump for provigil
  4. 2_TiReD

    2_TiReD New Member


    I have been on provigil for two months and am having pretty good luck with it. I could only tolerate about a quarter of a pill (approx. 50 mg) at a time at first, but can take 100 mg without a headache (drink lots of water!! I became dehydrated at first, hence the headache, I think) now.

    Haven't noticed an increase in yeasty-stuff yet and hope I don't , but have a super reduced appetite, which means I don't crave sugary stuff!! :) That has got to be helpful in fighting a candida problem.

    Good luck!

  5. Rafiki

    Rafiki New Member

    "Provigil does the opposite. Provigil does several things, but is mostly an NMDA-activator —it's a stimulant similar to cocaine—it will actually stimulate nitric oxide production. It may also stimulate ATP generation, which is the benefit perhaps that one sees. With more nitric oxide, you can think better, your memory improves, you can focus better, and you have more energy. But what you're doing is generating more peroxynitrite and this may not be felt for a while, but ultimately it's probably felt—in the brain at least—as Alzheimer's or Parkinson's Disease or worse, ten years from now."

  6. vueluv

    vueluv New Member

    Ive been on provigil for about a year now and really haven't had any problems with it and i am highly suseptible to yeast build up. I have sleep apnea in addition to fibro and this helps to keep me pretty alert.
  7. lucky

    lucky New Member

    I just started on Provigil 1 week ago and am so disappointed because all it does is make me more tired.
    Obviously it is not the right med for me, and I'll stop it the next couple of days.

    When I was on Ritalin a few years ago, I had instant success and could almost lead a normal life, but then a mini stroke struck me in 2005 and I was put on a very small dosage which does not give me any relief anymore.
    I have tried Strattera, no relief but more fatigue, now I don't know what to try next because I am sick and tired of the constant fatigue for the last 20 yrs.

    Take care, Lucky
  8. annade

    annade New Member

    Thanks for your reply. You are always a wealth of knowledge. I find it very interesting that your pendulum says I will not tolerate the provigil. I tried 50mg this morning and felt like I was on speed. Definitely gave me more energy, but I felt spacey and out of it. So your pendulum was right, it is not the drug for me.

    Can you ask it how I would do on Diflucan. Considering taking this medication for my systemis yeast issues? Thanks so much for your help. Hope your energy picks back up, sounds like you are doing so many great things for your body.


  9. PVLady

    PVLady New Member

    I have used Provigil off and on, especially when traveling. I take just 1/2 tablet. You don't even realize its effect except the fog lifts. One reaction I had was it caused me to have muscle pain. I don't have any idea why but it has happened more than once.

    I posted another idea about helping energy. I recently started using a vitamin/food shake called "Alive" whole food energizer. It is supposed to be the #1 mega nutrient. The ingredients are too long to list but you can check out on the web. I have a very sensitive stomach and had no problem.

    This stuff has been remarkable for me. I just did not have the "get up and go" and now I know why. I must have had borderline vitamin deficiencies.

    For years I could not eat much due to undiagnosed gallstones. Finally I had surgery in Nov. 2006 but by that time I had lost 50 lbs!

    By the way, if you decide to try it, they sell a really neat blender bottle at the health food store. It has a wire spring inside so when you shake the mix it really does the job.

    I am going to suggest to ProHealth they sell this product.

    [This Message was Edited on 05/30/2008]
  10. ScottInCalifornia82

    ScottInCalifornia82 New Member

    I tried it and had issues with it so I stopped. But these were just side effects that lasted while I was on the drug and maybe an hour or so after coming off the drug. It caused me to feel dizzy and absent minded and changed my personality a bit. No long term side effects or anything.

    I say you have nothing to lose. It has helped a lot of people with CFS. Try it out on a day off when you have no responsibilities. Whats the worse that can happen? You might feel crappy for a day but if it works you may benifit greatly from it.

  11. steach

    steach Member

    I had tried Provigil, and, unfortunatly, it did not give me the energy boost that I had hoped. I have also tried a couple of other medications, too, that did not help. My doctor finally put me on Adderall- 5mg in the morning BEFORE I get out of bed, then later in the afternoon. It really does work for me, although, I usually only take 2.5mg. The generic is very inexpensive. I only take it when I am having a really difficult time functioning. A bottle will last 4-5 months.

    Hope this helps.

  12. Mikie

    Mikie Moderator

    Like Lucky, Provigil just made me more tired. I usually don't take new meds but took some samples from my doc as a favor to him to see how it would affect me.

    Many docs are reporting concerns about meds which alter brain chemistry. Most of these drugs are too new to have decades of results on hand. Anything which alters dopamine in the brain concerns me because of the possibility of Parkinsonianism from long-term use. No one knows exactly how Provigil works but it does affect dopamine.

    Love, Mikie
  13. annade

    annade New Member

    Jaminhealth, thank you so very much for getting back to me on the diflucan and on the CS. I have actually taken both before and did feel better when I was strict with my diet and taking all the supplements to fight of yeast, but I got lazy and now I have to get more serious again. Thank you for reminding me about CS, I will start it again when I start the Diflucan. Thanks again for your insights and suggestions.

  14. tngirl

    tngirl New Member

    I have taken provigil, I have also taken adderall. Once I got the proper dosage of provigil it worked great. It was the closest to "normal" that I had felt in years. I had no side effects at all. Eventually it stopped working.

    then I switched to adderall. I didn't like it at first, I felt jittery and wired. After a few days that side effect left and I was able to take it. Eventually, my body got used to that one too.

    I have been resistant to drugs and take as few as I can to keep the pain at bay as much as possible.

    the fatigue is just as bad as the pain. with such horrible fatigue, my quality of life is awful.

    Provigil and Adderall improved my quality of life and for me it was worth it. With any drug you have to consider the pros and cons.
  15. UsedtobePerkyTina

    UsedtobePerkyTina New Member

    Before you start provigil, check out the sympathetic system abnormalities people CFS and FM have. It is for this reason that some CFS specialists don't recommend it.

  16. lucky

    lucky New Member

    and Thank You for your suggestion, but what type of glandular support would help and where can I get it?

    Take care, Lucky
  17. petcat

    petcat New Member

    I tried Provigil and it was a wonder drug, BUT, I have issues with PVC's and my heart went haywire after taking it. Too bad because I felt so good after taking it.
  18. steach

    steach Member

    Hi Mikie-

    It has been a while since I've been on the board/computer- it is great to see that you are still here!! I have a question for you.

    You mentioned dopamine in this thread. It made me wonder- does synthetic/natural dopamine used in medications have a correlation to Parkinson's? My doctor put me on Cymbalta to help with pain (and it does help). I believe that it either has synthetic dopamine in it -or- has an effect on dopamine recepters. This medication has also helped with "lifting my spirits", so to speak.

    Any info would be greatly appreciated.

  19. Mikie

    Mikie Moderator

    Good to see you here too. No one knows for sure how these meds will affect the brain and dopamine production/retention with long-term use. I do know that the meds eventually stop working in Parkinson's patients. People with Parkinson's Disease produce less and less dopamine in their brains. I do not believe the meds can cause Parkinson's Disease but it's possible they could cause a condition called, Parkinsonism (think I got that right) with symptoms which mimic Parkinson's. I have watched TV show segments and read articles where docs have raised this concern.

    I have the same concern with my Klonopin. I've been taking it a long time and would like to wean off of it. Dr. Cheney believes it protects the neurons in the brain. I may be well enough now that I can wean off of it without problems. If not, I will continue to take it because I would still need the GABA for sleep and sensory overload. I am concerned that if I take it for a very long time, my brain may not be able to produce, nor retain, the GABA. Again, no one knows. Klonopin has been around a long time and people have been taking it for long periods. Others have successfully weaned off. That makes me feel a bit better.

    Wish I could be of more help. It's just that no one knows for sure about these meds.

    Love, Mikie
  20. gapsych

    gapsych New Member

    I have found that Provigil really helps when I need the energy for important events. It also helps with the sensory overload.

    But, as you know, different people respond differently to meds.

    You might try it for a few days as for me, I immediately feel a difference. Other people have had different reactions.

    Also you may notice a headache at first so you might want to start on a lower dose at first. I do not get the headaches anymore.

    I only take 50 mg. which seems to work for me but that is a very low dose.

    I try not to take it everyday as I think it masks our need to rest. I rarely crash after taking this unless I do too much when on it.

    So I find that pacing, even when on the Provigil, is important.

    Hope you find the answer that works for you.