CRS Syndrome is "Can't Remember S*** Syndrome"--I hope you are laughing! My concern, however, is serious. I am on day 6 of 75 mg. Lyrica 2 times daily. It really seems to work--not necessarily for the fibro pain; it just kinda makes you not care about it--I suppose I'm in the euphoria phase. I have, however, been forgetting EVERYTHING. Today, for example, I finally found my sunglasses in my cutlery drawer--go figure! I went to pick up my "real" script today, as I have been on the famous "7 day free trial" and I found out that my insurance requires a prior authorization because they prefer neurontin. Is there any difference between the two? My pharm says there is. For one thing, Lyrica is a controlled substance. I guess I'm not sure why. Can anyone explain? I am also kinda nauseated. Is the honeymoon coming to an end? What can I expect? Do I need to ask my GP to increase the dose with time? For the record, I've had fibro for apprx. 3 yrs. I've also had several positive ANA--very high 1:1280-speckled pattern/ a moderately high rheumatoid factor, a moderately high westergren sed rate, etc. etc. Yet I have not been diagnosed with lupus or RA--fibro is my diagnosis. I've been to 4 rheums. One says I clearly have an "inflammatory arthritis", but he literally told me not to come back to him when the prednisone he put me on did absolutely nothing. I went to another rheum--an odd duck of a fellow who has been in practice for 30 yrs. He was so certain it was fibro and only fibro. He tried mirapex and requip; neither of which made much difference, so I quit both. (He did tell me to anticipate pregabalin. He knew it had some success. And I really liked him!) Stopped seeing him because he was actually out of my network, and I can't afford to go to docs that don't take my insurance. ANother rheum--one that I have waited 4 hrs. in his waiting room to see--also says fibro and gave me cymbalta--a drug that did nothing and was EVIL when I came off of it. It caused COLOSSAL withdrawal, and I will never take it again! And the 4 hr wait was just completely unacceptable. I would get so angry and agitatated waiting for my appointment that it had a negative effect on my health. I don't caRe how thorough a doctor is, if you have to routinely wait hours to see him/her, the doctor is overbooking. I too have a life, and I refuse to wait that long--I simply refuse! Next rheum--who was actually a NP, and she said fibro--maybe--and said maybe amitriptiline--i think--at night. I didn't agree to take it. Having come off cymbalta, I wasn't too quick to take anything else. My GP gave me lyrica last week. I was in the middle of a 3 wk flair when I saw her. I was in such pain. So far, I guess Lyrica is OK. I am 41--abruptly went through menopause at 37--and it's been downhill healthwise since. Personally, I've had alot of stress: hubby quit job and went to law school--while he did finish successfully and find another job, two major things happened: 1--we had a child--our first and only--in his 2nd year and I was 100% financially responsible for everything and solely responsible for the care of our daughter--he lived in another state, and I was here alone with absolutely no help from anyone--no family at all here and 2--we incurred $100,000 of law school debt. It's been a hard few years. I haven't gone crazy with stress and tension--menopause, mothering, massive debt, etc. , and I still smile everyday, but this may also be driving me to illness. Maybe I need a long overdue meltdown. Workwise I'm a tenured professor--a job i've held for 20 yrs. I won't bore you with my work garbage, but work, which is usually very consistent, has recently become unbearable in the stress factor--people getting fired, etc. I feel like a wreck most days, but I keep on going--like the d*** energizer bunny. I'm tired; I'm angry; I'm broke; I'm in pain. I'm even losing my religion. I need this community. Your support, I can't get anywhere else. At work, for example, most people don't even know i'm sick--and god knows, I am. An interesting part of my past is that I've had apprx 50 pints of blood transfused into me because of a problem I was born with. I always wonder if that caused my current problems, or if it's just my life's stress. Thoughts on this from what caused your fibro are so appreciated by me. In the college where I work, several women have developed it. One was a close friend. She told me she attended a workshop in CA and developed a sinus infection while there. On the plane trip home--to the east coast--she was miserable and never really recovered. She is now on disability. An old family doc I had said he thought cats cause some of the autoimmune diseases--and god knows, I've had my share of bites and scratches. Have you wondered what caused your illness? Is it an environmental factor? an emotional one? I just don't know. ALso, I had an aunt--paternal--who died from lupus and scleroderma--this makes me wonder. Hmmmm. What do you think made you sick? I'm convinced something did. My illness theory is this: there is always a genetic make-up that makes one vulnerable, but there is also always an environmental aggravator. Thoughts?