Seriphos,,for Adrenal glands,,tried it?

Discussion in 'Fibromyalgia Main Forum' started by razorqueen, Nov 17, 2006.

  1. razorqueen

    razorqueen Member

    I saw my Nauturopathic Dr today to get the results of my Saliva Tests I did. Well my Cortisol is way low in the mornings(no kidding) and are elavated during the day, and assuming high at night (that sample was incunclusive, will redo).

    So, to help elevate it in the am, I have to take a specific type of Licorice , and about 1hr before bedtime a product called Seriphos to bring it down.[2 capsules]

    I have posted info on this (Seriphos) so you can read it.

    I also need to take a certain kind of Vit B supplement that has extra B5 (need to get it) I will post exactly what it is called when I get it. It is a professional brand.


    Phosphorylated Serine (Phosphoserine) Adaptogen & Adrenal Support* DIETARY SUPPLEMENT

    Basic Chemistry

    Phosphatidyl Serine when consumed in food, for example egg yolks, or in a capsule provides about 20% of active Phosphorylated Serine (see #4 in Diagram 1). Each 100mg of Phosphatidyl Serine yields about 20mg of active phosphorylated serine following consumption. The bulk of the weight is derived from 2 fatty acids, R1 & R2.

    In the intestinal tract, the various enzymes (brush border and pancreatic) clip off the fatty acids, predominantly the unsaturated fatty acids. These fatty acids are not reassembled in the body to the stump molecule, rather different fatty acids are attached by the body to replace R1 and R2.

    The shaded glycerol molecule is very abundant in the body because it is found in all body fat and in dietary fats/oils in great abundance.

    In brief, the Phosphatidyl Serine acts as a precursor molecule and is not the active form of this nutrient. In our tissues, the rate limiting step is the phosphorylation of the serine molecule.

    In contrast, Phosphorylated Serine (brand name, SERIPHOS®) provides the activated or Phosphorylated Serine in a chelate form of magnesium and calcium.

    In the local tissue, the Phosphorylated Serine is linked to glycerol and the appropriate fatty acids specific to each tissue, and is not linked to the fatty acids provided in the precursor Phosphatidyl Serine.

    Phosphorylated Serine (brand name, SERIPHOS®) is a pure product not derived from animal tissue. The serine is from vegetable sources and the phosphate is from a pure phosphate donor compound.

    Excerpts & Abstracts on the Use of Phosphorylated Serine

    Early Cortisol Escape Phenomenon Reversed by Phophatidyl Serine In Elderly Normal Subjects. Nerozzi, Dina et al, Clincal Trials Journal, 1-89, vol 26 (1).


    The early cortisol escape phenomenon observed after administration of 1mg of dexamethasone in 50% of the elderly subjects in the study was reversed by two months therapy with Phosphatidyl Serine (PS), 3 x 100mg tablets daily.

    An action of the compound at the neurotransmitter level is hypothesized.

    A number of alterations of the *HPAA was detectable in our study in normal elderly subjects; abnormal elevation of basal morning cortisol values (3 subjects); disruption of the circadian cortisol pattern (4 subjects); early cortisol escape phenomenon observed in seven of our subjects. A true non-suppression was visible only in two individuals. Therefore, the early cortisol escape phenomenon appears to be the most consistent abnormality found in our subjects.

    The question of contribution of non-specific stress factors to cortisol hypersecretion obviously cannot be ruled out. However, in our opinion, an intrinsic neuro-endocrine disturbance, which may be part of a central dysfunction associated with aging, could be at the root of a substantial part of the hypersecretion.

    According to the membrane hypothesis of aging (1), age-dependent changes of the membranes can negatively interfere with trophism of the neurons, with cell to cell communication and ultimately with neurotransmission and thus with most functions linked to neurotransmission, including hormonal secretion.

    *HPAA: Hypothalmic Pituitary Adrenal Axis

    According to Massarotti (2), PS seems to stimulate some sort of morphogenetic neuronal plasticity, which acts as a compensatory adaptive mechanism to cell deterioration, and is capable of preventing or delaying the age dependent decline of neurotransmitter function. On the basis of our findings we can speculate that existence of an analogous mechanism which acts on neurotransmission similar to that observed in animals treated with PS.

    However, when we consider the impairment of HPAA as a marker of a more central neurotransmitter imbalance, we can suppose that the readjustment of such an altered parameter, although partial, may be brought about by some action at the neurotransmitter level.

    Sund & Sun, Top. Geront., 1979; 15:34-53. Massarotti. M. In: Bes A, ed. Senile Dementias. Effects of Phosphatidyl Serine in Age Associated Memory Impairment T.H. Crook. Ph.D.; J. Tinklenberg. MD; J. Yesavage, MD; W. Petrie, ML); M.G. Nunzi, Ph.D; and D.C. Massari, Ph.D.; Neurology, 1991; 41:611-649.

    Summary We treated 149 patients meeting criteria of age associated memory impairment (AAMI) for 12 weeks with a formulation of Phosphatidyl Serine (100-150mg PS bid) or placebo.

    Patients treated with the compound improved, relative to those untreated, with learning and memory tasks of daily life.

    Analysis of clinical subgroup suggested that persons within the sample who performed at a relatively low level prior to treatment were most likely to respond to PS. Within this subgroup, there was improvement on both computerized and standard neuropsychological performance tests, and also on clinical global ratings of improvement. The results suggest that the compound may be a promising candidate for treating memory loss in later life.


    Proprietary Blend: Phosphoserine and Ethanolamine 1,000 mg

    Other ingredients: Gelatin.

    Suggested usage:

    Like all macro minerals, it is best absorbed when taken before meals or before bedtime at least 15 minutes before eating. For stress, take one capsule at least 15 minutes before eating.

    NOTE: Seriphos works with the pineal gland. Take two in the morning and two at lunch time before meals for better sleep at nighttime. This mimics the cortisol "curve".

    [This Message was Edited on 11/17/2006]
  2. Kombucha

    Kombucha New Member

    I was a patient of Poesnecker/Clymer/Chronic Fatigue place.

    I had the reverse cortisol curve. Low in morning, high at night.

    I was on Seriphos for months, it did seem to improve quality of sleep, but I think it also made me more tired in the day.

    I tried the solid licorice, and gained nothing but water weight and felt bad. Same with DHEA same with Pregnenolone. And their adrenal supplement I forgot the name, this was several years ago, I think was a waste of money. I think the entire thing wasn't worth the money! Your results could be different.

    Had I to do this over again after getting saliva/cortisol results I would go on a true low carb diet like Life Without Bread, or Protein Power Lifeplan and then I would have retested to see if really controlling insulin helped the adrenal disfunction and allowed for a normalization of hormonal output. But I don't have to redo this, because I'm doing it right now! I'm on a less then 72 gram carb diet in a few months (6month marker) I'm going to retest, if it is still dysfunctional I'm going to seek out bioidentical cortisol and give that a try.

    Good luck,
    [This Message was Edited on 11/18/2006]
  3. Jeanne-in-Canada

    Jeanne-in-Canada New Member

  4. Juloo

    Juloo Member

    I started several years ago w/Poesnecker. I got up to about 12 a day before it knocked out the cortisol overproduction. It helped a lot. I still keep it around the house when I feel like things are revving up again out of control. Since it is supposed to turn off the cortisol overload switch, you should expect to feel less energy during the day. It's as if your body is a car, idling in the driveway -- but instead of idling like we'd think, someone's wedged the gas pedal all the way down and causing the gas tank to drain dry. Seriphos is like someone un-wedging the gas pedal.
  5. kholmes

    kholmes New Member

    Several years ago, a ASI/Saliva test showed that I had a similar adrenal profile. I've been taking Seriphos ever since. Usually, I take three, and for me, it works best if I take it in the evening. Seriphos is one of the few products that I've found that really help over the years. It helps me to sleep better and it helps reduce the wired, shaky feeling I get.
  6. razorqueen

    razorqueen Member

    for the responses. DOn't have time to get my new supplements together to name them all and give the brand names.

    Took the licorice this morning,, YUCK!!! I hope I can do it!

    p.s. Kholmes,,, how long did it take for it to start working?[This Message was Edited on 11/18/2006]

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