Severe Doubt Over CFS/XMRV link

Discussion in 'Fibromyalgia Main Forum' started by hahaha, May 31, 2011.

  1. hahaha

    hahaha New Member

    Just read this article which states the Science Journal has asked the authors of the study which linked CFS with XMRV to withdraw their findings after 10 subsequent studies failed to find the same link:
  2. quanked

    quanked Member

    Kind of disheartening to me but better to know this is happening than not.

    Primary source for bbc's article below


    Editorial Expression of Concern
    Bruce Alberts

    In the issue of 23 October 2009, Science published the Report “Detection of an infectious retrovirus, XMRV, in blood cell of patients with chronic fatigue syndrome,” a study by Lombardi et al. purporting to show that a retrovirus called XMRV (xenotropic murine leukemia virus-related virus) was present in the blood of 67% of patients with chronic fatigue syndrome (CFS) compared with 3.7% of healthy controls (1). Since then, at least 10 studies conducted by other investigators and published elsewhere have reported a failure to detect XMRV in independent populations of CFS patients. In this week’s edition of Science Express, we are publishing two Reports that strongly support the growing view that the association between XMRV and CFS described by Lombardi et al. likely reflects contamination of laboratories and research reagents with the virus. In the first Report, “Recombinant origin of the retrovirus XMRV” (2), T. Paprotka et al. trace the ancestry of XMRV and provide evidence that the virus originated when two mouse leukemia viruses underwent recombination during experimental passage of a human prostate tumor xenograft in mice in the 1990s. A combination of sequencing, phylogenetic, and probability analyses lead Paprotka et al. to conclude that laboratory contamination with XMRV produced by a cell line (22Rv1) derived from these early xenograft experiments is the most likely explanation for detection of the virus in patient samples. In the second Report, “No evidence of murine-like gammaretroviruses in CFS patients previously identified as XMRV-infected” (3), K. Knox et al. examined blood samples from 61 CFS patients from the same medical practice that had provided patient samples to Lombardi et al. Comprehensive assays by Knox et al. for viral nucleic acids, infectious virus, and virus-specific antibodies revealed no evidence of XMRV in any of the samples.

    The study by Lombardi et al. (1) attracted considerable attention, and its publication in Science has had a far-reaching impact on the community of CFS patients and beyond. Because the validity of the study by Lombardi et al. is now seriously in question, we are publishing this Expression of Concern and attaching it to Science’s 23 October 2009 publication by Lombardi et al.
    The U.S. National Institutes of Health is sponsoring additional carefully designed studies to ascertain whether the association between XMRV and CFS can be confirmed. Science eagerly awaits the outcome of these further studies and will take appropriate action when their results are known.
    1. V. C. Lombardi et al., Science 326, 585 (2009); published online 8 October 2009 (10.1126/science.1179052).
    2. T. Paprotka et al., Science, published online 31 May 2011 (10.1126/science.1205292).
    3. K. Knox et al., Science, published online 31 May 2011 (10.1126/science.1204963).
    17 May 2011; accepted 26 May 2011 Published online 31 May 2011; 10.1126/science.1208542 Include this information when citing this paper. / 31 May 2011 / Page 1/ 10.1126/science.1208542
    [This Message was Edited on 05/31/2011]
  3. mbofov

    mbofov Active Member

    can they ask WPI to retract their paper, when the NIH/FDA study ( found overwhelming evidence for the presence of XMRV in CFS patients?